Histidines 13 and 14 in the Aβ sequence are targets for inhibition of Alzheimer's disease Aβ ion channel and cytotoxicity

Histidines 13 and 14 in the Aβ sequence are targets for inhibition of Alzheimer's disease Aβ ion channel and cytotoxicity

The fact that Alzheimer's beta amyloid (Aβ) peptides forms cation channels in lipid bilayers was discovered during the course of our experiments in the laboratory of "Guayo" Rojas at NIH in Bethesda, Maryland (USA). Recently, we found that the Aβ ion channel could be...

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Autores principales: DÍAZ,JUAN CARLOS, LINNEHAN,JOHN, POLLARD,HARVEY, ARISPE,NELSON
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2006
Materias:
Alzheimer's disease
beta amyloid
ion channel blockers
peptides
histidine
toxicity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300007
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