Effect of the zinc chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) on hippocampal mossy fiber calcium signals and on synaptic transmission

Effect of the zinc chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) on hippocampal mossy fiber calcium signals and on synaptic transmission

An important pool of chelatable zinc is present in the synaptic vesicles of mossy fiber terminals from hippocampal CA3 area, being zinc released following single or repetitive electrical stimulation. Previous studies have suggested different synaptic roles for released mossy fiber zinc, including th...

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Autores principales: MATIAS,CARLOS M, MATOS,NUNO C, ARIF,MONA, DIONISIO,JOSE C, QUINTA-FERREIRA,M EMILIA
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2006
Materias:
mossy fiber synapses
long-term potentiation (LTP)
Area CA3
presynaptic calcium
Fura-2
Area CA1
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300013
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