The role of thyroid hormone calorigenesis in the redox regulation of gene expression

Thyroid hormone (TH; 3,3',5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on 0(2) consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response...

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Autores principales:	VARELA,PATRICIA, TAPIA,GLADYS, FERNÁNDEZ,VIRGINIA, VIDELA,LUIS A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	Thyroid hormone Calorigenesis Oxidative stress Gene expression
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500004
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spelling	oai:scielo:S0716-976020060005000042007-08-06The role of thyroid hormone calorigenesis in the redox regulation of gene expressionVARELA,PATRICIATAPIA,GLADYSFERNÁNDEZ,VIRGINIAVIDELA,LUIS A Thyroid hormone Calorigenesis Oxidative stress Gene expression Thyroid hormone (TH; 3,3',5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on 0(2) consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response elements or the activation of intermediate factors, with the consequent higher production of reactive 0(2) species (ROS) and antioxidant depletion. T3-induced oxidative stress in the liver triggers the redox upregulation of the expression of cytokines (tumor necrosis factor-á [TNF-á], interleukin-10), enzymes (inducible nitric oxide synthase, manganese superoxide dismutase), and anti-apoptotic proteins (Bcl-2), via a cascade initiated by TNF-á produced by Kupffer cells, involving inhibitor of κB phosphorylation and nuclear factor-κB activation. Thus, TH calorigenesis triggers an expression pattern that may represent an adaptive mechanism to re-establish redox homeostasis and promote cell survival under conditions of ROS toxicity secondary to TH-induced oxidative stress. Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunctioninfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.4 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500004en10.4067/S0716-97602006000500004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thyroid hormone Calorigenesis Oxidative stress Gene expression
spellingShingle	Thyroid hormone Calorigenesis Oxidative stress Gene expression VARELA,PATRICIA TAPIA,GLADYS FERNÁNDEZ,VIRGINIA VIDELA,LUIS A The role of thyroid hormone calorigenesis in the redox regulation of gene expression
description	Thyroid hormone (TH; 3,3',5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on 0(2) consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response elements or the activation of intermediate factors, with the consequent higher production of reactive 0(2) species (ROS) and antioxidant depletion. T3-induced oxidative stress in the liver triggers the redox upregulation of the expression of cytokines (tumor necrosis factor-á [TNF-á], interleukin-10), enzymes (inducible nitric oxide synthase, manganese superoxide dismutase), and anti-apoptotic proteins (Bcl-2), via a cascade initiated by TNF-á produced by Kupffer cells, involving inhibitor of κB phosphorylation and nuclear factor-κB activation. Thus, TH calorigenesis triggers an expression pattern that may represent an adaptive mechanism to re-establish redox homeostasis and promote cell survival under conditions of ROS toxicity secondary to TH-induced oxidative stress. Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunction
author	VARELA,PATRICIA TAPIA,GLADYS FERNÁNDEZ,VIRGINIA VIDELA,LUIS A
author_facet	VARELA,PATRICIA TAPIA,GLADYS FERNÁNDEZ,VIRGINIA VIDELA,LUIS A
author_sort	VARELA,PATRICIA
title	The role of thyroid hormone calorigenesis in the redox regulation of gene expression
title_short	The role of thyroid hormone calorigenesis in the redox regulation of gene expression
title_full	The role of thyroid hormone calorigenesis in the redox regulation of gene expression
title_fullStr	The role of thyroid hormone calorigenesis in the redox regulation of gene expression
title_full_unstemmed	The role of thyroid hormone calorigenesis in the redox regulation of gene expression
title_sort	role of thyroid hormone calorigenesis in the redox regulation of gene expression
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500004
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The role of thyroid hormone calorigenesis in the redox regulation of gene expression

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