Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxida...

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Autores principales:	PEJIC,SNEZANA, KASAPOVIC,JELENA, TODOROVIC,ANA, STOJILJKOVIC,VESNA, PAJOVIC,SNEZANA B
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2006
Materias:	antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005
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spelling	oai:scielo:S0716-976020060005000052007-08-06Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometriumPEJIC,SNEZANAKASAPOVIC,JELENATODOROVIC,ANASTOJILJKOVIC,VESNAPAJOVIC,SNEZANA B antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myomainfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.39 n.4 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005en10.4067/S0716-97602006000500005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma
spellingShingle	antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma PEJIC,SNEZANA KASAPOVIC,JELENA TODOROVIC,ANA STOJILJKOVIC,VESNA PAJOVIC,SNEZANA B Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
description	Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma
author	PEJIC,SNEZANA KASAPOVIC,JELENA TODOROVIC,ANA STOJILJKOVIC,VESNA PAJOVIC,SNEZANA B
author_facet	PEJIC,SNEZANA KASAPOVIC,JELENA TODOROVIC,ANA STOJILJKOVIC,VESNA PAJOVIC,SNEZANA B
author_sort	PEJIC,SNEZANA
title	Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
title_short	Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
title_full	Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
title_fullStr	Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
title_full_unstemmed	Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
title_sort	lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
publisher	Sociedad de Biología de Chile
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005
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Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium

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