Antioxidant activity of extract from Polygonum cuspidatum

Numerous diseases are induced by free radicals via lipid peroxidation, protein peroxidation and DNA damage. It has been known that a variety of plant extracts have antioxidant activities to scavenge free radicals. Whether Polygonum cuspidatum Sieb. et Zuce has antioxidant activity is unknown. In thi...

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Autores principales:	HSU,CHIN-YUAN, CHAN,YU-PEI, CHANG,JELI
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	antioxidant activity free radicals phenolics lipid peroxidation DNA damage Polygonum cuspidatum
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000100002
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spelling	oai:scielo:S0716-976020070001000022007-11-15Antioxidant activity of extract from Polygonum cuspidatumHSU,CHIN-YUANCHAN,YU-PEICHANG,JELI antioxidant activity free radicals phenolics lipid peroxidation DNA damage Polygonum cuspidatum Numerous diseases are induced by free radicals via lipid peroxidation, protein peroxidation and DNA damage. It has been known that a variety of plant extracts have antioxidant activities to scavenge free radicals. Whether Polygonum cuspidatum Sieb. et Zuce has antioxidant activity is unknown. In this study, dried roots of Polygonum cuspidatum were extracted by ethanol and the extract was lyophilized. Free radical scavenging assays, superoxide radical scavenging assays, lipid peroxidation assays and hydroxyl radical-induced DNA strand scission assays were employed to study antioxidant activities. The results indicate that the IC50 value oí Polygonum cuspidatum extract is 110 µg/ml in free radical scavenging assays, 3.2 µg/ml in superoxide radical scavenging assays, and 8 µg/ml in lipid peroxidation assays, respectively. Furthermore, Polygonum cuspidatum extract has DNA protective effect in hydroxyl radical-induced DNA strand scission assays. The total phenolics and flavonoid content of extract is 641.1 ± 42.6 mg/g and 62.3 ± 6.0 mg/g. The results indicate that Polygonum cuspidatum extract clearly has antioxidant effectsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.1 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000100002en10.4067/S0716-97602007000100002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidant activity free radicals phenolics lipid peroxidation DNA damage Polygonum cuspidatum
spellingShingle	antioxidant activity free radicals phenolics lipid peroxidation DNA damage Polygonum cuspidatum HSU,CHIN-YUAN CHAN,YU-PEI CHANG,JELI Antioxidant activity of extract from Polygonum cuspidatum
description	Numerous diseases are induced by free radicals via lipid peroxidation, protein peroxidation and DNA damage. It has been known that a variety of plant extracts have antioxidant activities to scavenge free radicals. Whether Polygonum cuspidatum Sieb. et Zuce has antioxidant activity is unknown. In this study, dried roots of Polygonum cuspidatum were extracted by ethanol and the extract was lyophilized. Free radical scavenging assays, superoxide radical scavenging assays, lipid peroxidation assays and hydroxyl radical-induced DNA strand scission assays were employed to study antioxidant activities. The results indicate that the IC50 value oí Polygonum cuspidatum extract is 110 µg/ml in free radical scavenging assays, 3.2 µg/ml in superoxide radical scavenging assays, and 8 µg/ml in lipid peroxidation assays, respectively. Furthermore, Polygonum cuspidatum extract has DNA protective effect in hydroxyl radical-induced DNA strand scission assays. The total phenolics and flavonoid content of extract is 641.1 ± 42.6 mg/g and 62.3 ± 6.0 mg/g. The results indicate that Polygonum cuspidatum extract clearly has antioxidant effects
author	HSU,CHIN-YUAN CHAN,YU-PEI CHANG,JELI
author_facet	HSU,CHIN-YUAN CHAN,YU-PEI CHANG,JELI
author_sort	HSU,CHIN-YUAN
title	Antioxidant activity of extract from Polygonum cuspidatum
title_short	Antioxidant activity of extract from Polygonum cuspidatum
title_full	Antioxidant activity of extract from Polygonum cuspidatum
title_fullStr	Antioxidant activity of extract from Polygonum cuspidatum
title_full_unstemmed	Antioxidant activity of extract from Polygonum cuspidatum
title_sort	antioxidant activity of extract from polygonum cuspidatum
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000100002
work_keys_str_mv	AT hsuchinyuan antioxidantactivityofextractfrompolygonumcuspidatum AT chanyupei antioxidantactivityofextractfrompolygonumcuspidatum AT changjeli antioxidantactivityofextractfrompolygonumcuspidatum
_version_	1718441411723919360

Antioxidant activity of extract from Polygonum cuspidatum

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