Toll-like Receptors are Key Participants in Innate Immune Responses

During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. Th...

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Autores principales:	ARANCIBIA,SERGIO A, BELTRÁN,CAROLL J, AGUIRRE,ISABEL M, SILVA,PAULINA, PERALTA,ALEXIS L, MALINARICH,FRANO, HERMOSO,MARCELA A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	Toll-like receptors Innate Immunity cytokines MyD88 NFkB
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001
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spelling	oai:scielo:S0716-976020070002000012008-06-13Toll-like Receptors are Key Participants in Innate Immune ResponsesARANCIBIA,SERGIO ABELTRÁN,CAROLL JAGUIRRE,ISABEL MSILVA,PAULINAPERALTA,ALEXIS LMALINARICH,FRANOHERMOSO,MARCELA A Toll-like receptors Innate Immunity cytokines MyD88 NFkB During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review articleinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.2 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001en10.4067/S0716-97602007000200001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Toll-like receptors Innate Immunity cytokines MyD88 NFkB
spellingShingle	Toll-like receptors Innate Immunity cytokines MyD88 NFkB ARANCIBIA,SERGIO A BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A Toll-like Receptors are Key Participants in Innate Immune Responses
description	During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article
author	ARANCIBIA,SERGIO A BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A
author_facet	ARANCIBIA,SERGIO A BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A
author_sort	ARANCIBIA,SERGIO A
title	Toll-like Receptors are Key Participants in Innate Immune Responses
title_short	Toll-like Receptors are Key Participants in Innate Immune Responses
title_full	Toll-like Receptors are Key Participants in Innate Immune Responses
title_fullStr	Toll-like Receptors are Key Participants in Innate Immune Responses
title_full_unstemmed	Toll-like Receptors are Key Participants in Innate Immune Responses
title_sort	toll-like receptors are key participants in innate immune responses
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001
work_keys_str_mv	AT arancibiasergioa tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT beltrancarollj tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT aguirreisabelm tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT silvapaulina tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT peraltaalexisl tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT malinarichfrano tolllikereceptorsarekeyparticipantsininnateimmuneresponses AT hermosomarcelaa tolllikereceptorsarekeyparticipantsininnateimmuneresponses
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Toll-like Receptors are Key Participants in Innate Immune Responses

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