Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects

Introduction: Advanced glycoxidation end-products (AGEs) are involved in age-related conditions and diabetic complications. Diet intake contributes to their circulating concentrations. Aim: To measure serum and urinary AGEs in non-diabetic volunteers and relate their concentration to body compositio...

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Autores principales:	DE LA MAZA,MP, BRAVO,A, LEIVA,L, GATTÁS,V, PETERMANN,M, GARRIDO,F, BUNOUT,D, HIRSCH,S, BARRERA,G, FERNÁNDEZ,M
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	Advanced glycation end-products fluorescent AGEs glycoxidation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200011
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spelling	oai:scielo:S0716-976020070002000112008-06-13Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjectsDE LA MAZA,MPBRAVO,ALEIVA,LGATTÁS,VPETERMANN,MGARRIDO,FBUNOUT,DHIRSCH,SBARRERA,GFERNÁNDEZ,M Advanced glycation end-products fluorescent AGEs glycoxidation Introduction: Advanced glycoxidation end-products (AGEs) are involved in age-related conditions and diabetic complications. Diet intake contributes to their circulating concentrations. Aim: To measure serum and urinary AGEs in non-diabetic volunteers and relate their concentration to body composition, blood chemistry and dietary ingestión. Methods: We studied 41 adult men (31 middle-aged adults and 10 elderly). A nutritional assessment including a dietary recall designed for detection of AGE ingestión (specifically carboxymethyl-lysine(CML)), and anthropometric measurements were performed. Also serum lipoproteins, insulin, glucose, leptin and C reactive protein (CRP). AGEs were measured in serum and urine samples using size exclusion chromatography and flow injection assay (FIA); the technical procedures were first employed in 11 heterogeneous diabetics, as positive controls for this methodology. Results: Serum and urinary chromatograms indicated that areas under the curve were not different in younger compared with elderly adults. AGEs did not correlate with dietary intake, body composition, nor metabolic parameters, however they correlated significantly with renal function and CRP concentration. Discussion: In these non-diabetic volunteers, with low CML intake, serum and urinary concentration of AGEs were not related to dietary intake. AGEs were related to renal function and CRP, but not to body composition, lipoproteins, insulin and glucoseinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.2 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200011en10.4067/S0716-97602007000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Advanced glycation end-products fluorescent AGEs glycoxidation
spellingShingle	Advanced glycation end-products fluorescent AGEs glycoxidation DE LA MAZA,MP BRAVO,A LEIVA,L GATTÁS,V PETERMANN,M GARRIDO,F BUNOUT,D HIRSCH,S BARRERA,G FERNÁNDEZ,M Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
description	Introduction: Advanced glycoxidation end-products (AGEs) are involved in age-related conditions and diabetic complications. Diet intake contributes to their circulating concentrations. Aim: To measure serum and urinary AGEs in non-diabetic volunteers and relate their concentration to body composition, blood chemistry and dietary ingestión. Methods: We studied 41 adult men (31 middle-aged adults and 10 elderly). A nutritional assessment including a dietary recall designed for detection of AGE ingestión (specifically carboxymethyl-lysine(CML)), and anthropometric measurements were performed. Also serum lipoproteins, insulin, glucose, leptin and C reactive protein (CRP). AGEs were measured in serum and urine samples using size exclusion chromatography and flow injection assay (FIA); the technical procedures were first employed in 11 heterogeneous diabetics, as positive controls for this methodology. Results: Serum and urinary chromatograms indicated that areas under the curve were not different in younger compared with elderly adults. AGEs did not correlate with dietary intake, body composition, nor metabolic parameters, however they correlated significantly with renal function and CRP concentration. Discussion: In these non-diabetic volunteers, with low CML intake, serum and urinary concentration of AGEs were not related to dietary intake. AGEs were related to renal function and CRP, but not to body composition, lipoproteins, insulin and glucose
author	DE LA MAZA,MP BRAVO,A LEIVA,L GATTÁS,V PETERMANN,M GARRIDO,F BUNOUT,D HIRSCH,S BARRERA,G FERNÁNDEZ,M
author_facet	DE LA MAZA,MP BRAVO,A LEIVA,L GATTÁS,V PETERMANN,M GARRIDO,F BUNOUT,D HIRSCH,S BARRERA,G FERNÁNDEZ,M
author_sort	DE LA MAZA,MP
title	Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
title_short	Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
title_full	Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
title_fullStr	Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
title_full_unstemmed	Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
title_sort	fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200011
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Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects

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