The CK1 gene family: expression patterning in zebrafish development
Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus. Several isoforms of this gene family have been described in various organisms: CK1á, CK1ß, CK1δ, CK1å and CK1γ. Over th...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2007
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oai:scielo:S0716-976020070002000152008-06-13The CK1 gene family: expression patterning in zebrafish developmentALBORNOZ,AMELINAYÁÑEZ,JOSÉ MFOERSTER,CLAUDIAAGUIRRE,CELESTEPEREIRO,LUISABURZIO,VERÓNICAMORAGA,MAURICIOREYES,ARIEL EANTONELLI,MARCELO CK1 Casein Kinase 1 Expression pattern Development Zebrafish otic vesicles retina lens pectoral fin bud tegmentum myelencephalon telencephalon diencephalon mesencephalon rhombomeres Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus. Several isoforms of this gene family have been described in various organisms: CK1á, CK1ß, CK1δ, CK1å and CK1γ. Over the last decade, several members of this family have been involved in development processes related to wnt and sonic hedgehog signalling pathways. However, there is no detailed temporal information on the CK1 family in embryonic stages, even though orthologous genes have been described in several different vertebrate species. In this study, we describe for the first time the cloning and detailed expression pattern of five CK1 zebrafish genes. Sequence analysis revealed that zebrafish CK1 proteins are highly homologous to other vertebrate orthologues. Zebrafish CK1 genes are expressed throughout development in common and different territories. All the genes studied in development show maternal and zygotic expression with the exception of CK1å. This last gene presents only a zygotic component of expression. In early stages of development CK1 genes are ubiquitously expressed with the exception of CK1å. In later stages the five CK1 genes are expressed in the brain but not in the same way. This observation probably implicates the CK1 family genes in different and also in redundant functions. This is the first time that a detailed comparison of the expression of CK1 family genes is directly assessed in a vertebrate system throughout developmentinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.2 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200015en10.4067/S0716-97602007000200015 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
CK1 Casein Kinase 1 Expression pattern Development Zebrafish otic vesicles retina lens pectoral fin bud tegmentum myelencephalon telencephalon diencephalon mesencephalon rhombomeres |
| spellingShingle |
CK1 Casein Kinase 1 Expression pattern Development Zebrafish otic vesicles retina lens pectoral fin bud tegmentum myelencephalon telencephalon diencephalon mesencephalon rhombomeres ALBORNOZ,AMELINA YÁÑEZ,JOSÉ M FOERSTER,CLAUDIA AGUIRRE,CELESTE PEREIRO,LUISA BURZIO,VERÓNICA MORAGA,MAURICIO REYES,ARIEL E ANTONELLI,MARCELO The CK1 gene family: expression patterning in zebrafish development |
| description |
Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus. Several isoforms of this gene family have been described in various organisms: CK1á, CK1ß, CK1δ, CK1å and CK1γ. Over the last decade, several members of this family have been involved in development processes related to wnt and sonic hedgehog signalling pathways. However, there is no detailed temporal information on the CK1 family in embryonic stages, even though orthologous genes have been described in several different vertebrate species. In this study, we describe for the first time the cloning and detailed expression pattern of five CK1 zebrafish genes. Sequence analysis revealed that zebrafish CK1 proteins are highly homologous to other vertebrate orthologues. Zebrafish CK1 genes are expressed throughout development in common and different territories. All the genes studied in development show maternal and zygotic expression with the exception of CK1å. This last gene presents only a zygotic component of expression. In early stages of development CK1 genes are ubiquitously expressed with the exception of CK1å. In later stages the five CK1 genes are expressed in the brain but not in the same way. This observation probably implicates the CK1 family genes in different and also in redundant functions. This is the first time that a detailed comparison of the expression of CK1 family genes is directly assessed in a vertebrate system throughout development |
| author |
ALBORNOZ,AMELINA YÁÑEZ,JOSÉ M FOERSTER,CLAUDIA AGUIRRE,CELESTE PEREIRO,LUISA BURZIO,VERÓNICA MORAGA,MAURICIO REYES,ARIEL E ANTONELLI,MARCELO |
| author_facet |
ALBORNOZ,AMELINA YÁÑEZ,JOSÉ M FOERSTER,CLAUDIA AGUIRRE,CELESTE PEREIRO,LUISA BURZIO,VERÓNICA MORAGA,MAURICIO REYES,ARIEL E ANTONELLI,MARCELO |
| author_sort |
ALBORNOZ,AMELINA |
| title |
The CK1 gene family: expression patterning in zebrafish development |
| title_short |
The CK1 gene family: expression patterning in zebrafish development |
| title_full |
The CK1 gene family: expression patterning in zebrafish development |
| title_fullStr |
The CK1 gene family: expression patterning in zebrafish development |
| title_full_unstemmed |
The CK1 gene family: expression patterning in zebrafish development |
| title_sort |
ck1 gene family: expression patterning in zebrafish development |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2007 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200015 |
| work_keys_str_mv |
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