Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep

Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess o...

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Autores principales:	RECABARREN,SERGIO E, LOBOS,ALEJANDRO, FIGUEROA,YARA, PADMANABHAN,VASANTHA, FOSTER,DOUGLAS L, SIR-PETERMANN,TERESA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	fetal programming IUGR Pituitary sensitivity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400007
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spelling	oai:scielo:S0716-976020070004000072008-04-17Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheepRECABARREN,SERGIO ELOBOS,ALEJANDROFIGUEROA,YARAPADMANABHAN,VASANTHAFOSTER,DOUGLAS LSIR-PETERMANN,TERESA fetal programming IUGR Pituitary sensitivity Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg), as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the response curve (AUC) of LH increased progressively in both controls and prenatal T-treated males from 5 to 20 weeks of age (P<0.01). The LH responses in prenatal T-treated males were lower at 20 and 30 weeks of age compared to controls (P<0.05). AUC-T increased progressively in control males from 5 through 30 weeks of age and prenatal T-treated males from 5 to 20 weeks of age. The T response in prenatal T-treated males was higher at 20 weeks compared to controls of same age but similar to controls and prenatal T-treated males at 30 weeks of age (P <0.05). Our findings suggest that prenatal T treatment advances the developmental trajectory of gonadal responsiveness to GnRH in male offspringinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.3 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400007en10.4067/S0716-97602007000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	fetal programming IUGR Pituitary sensitivity
spellingShingle	fetal programming IUGR Pituitary sensitivity RECABARREN,SERGIO E LOBOS,ALEJANDRO FIGUEROA,YARA PADMANABHAN,VASANTHA FOSTER,DOUGLAS L SIR-PETERMANN,TERESA Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
description	Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg), as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the response curve (AUC) of LH increased progressively in both controls and prenatal T-treated males from 5 to 20 weeks of age (P<0.01). The LH responses in prenatal T-treated males were lower at 20 and 30 weeks of age compared to controls (P<0.05). AUC-T increased progressively in control males from 5 through 30 weeks of age and prenatal T-treated males from 5 to 20 weeks of age. The T response in prenatal T-treated males was higher at 20 weeks compared to controls of same age but similar to controls and prenatal T-treated males at 30 weeks of age (P <0.05). Our findings suggest that prenatal T treatment advances the developmental trajectory of gonadal responsiveness to GnRH in male offspring
author	RECABARREN,SERGIO E LOBOS,ALEJANDRO FIGUEROA,YARA PADMANABHAN,VASANTHA FOSTER,DOUGLAS L SIR-PETERMANN,TERESA
author_facet	RECABARREN,SERGIO E LOBOS,ALEJANDRO FIGUEROA,YARA PADMANABHAN,VASANTHA FOSTER,DOUGLAS L SIR-PETERMANN,TERESA
author_sort	RECABARREN,SERGIO E
title	Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
title_short	Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
title_full	Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
title_fullStr	Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
title_full_unstemmed	Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
title_sort	prenatal testosterone treatment alters lh and testosterone responsiveness to gnrh agonist in male sheep
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400007
work_keys_str_mv	AT recabarrensergioe prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep AT lobosalejandro prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep AT figueroayara prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep AT padmanabhanvasantha prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep AT fosterdouglasl prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep AT sirpetermannteresa prenataltestosteronetreatmentalterslhandtestosteroneresponsivenesstognrhagonistinmalesheep
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Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep

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