High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be i...

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Autores principales:	GUZMAN,LEDA M, KORIYAMA,CHIHAYA, AKIBA,SUMINORI, EIZURU,YOSHITO, CASTILLO,DARWINS, CORVALAN,ALEJANDRO, AGUAYO,FRANCISCO R
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	lung carcinoma methylation promoter region
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400011
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spelling	oai:scielo:S0716-976020070004000112008-04-17High frequency of p 16 promoter methylation in non-small cell lung carcinomas from ChileGUZMAN,LEDA MKORIYAMA,CHIHAYAAKIBA,SUMINORIEIZURU,YOSHITOCASTILLO,DARWINSCORVALAN,ALEJANDROAGUAYO,FRANCISCO R lung carcinoma methylation promoter region The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7% (59/74). When we considered histological type, we observed that p16 promoter methylation was significantly higher in squamous cell carcinomas (30/33, 91%) compared with adenocarcinomas (21/30, 70%) (p=0.029). In addition, no association between p16 promoter methylation and gender, age or smoking habit was found (p=0.202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independentinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.3 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400011en10.4067/S0716-97602007000400011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	lung carcinoma methylation promoter region
spellingShingle	lung carcinoma methylation promoter region GUZMAN,LEDA M KORIYAMA,CHIHAYA AKIBA,SUMINORI EIZURU,YOSHITO CASTILLO,DARWINS CORVALAN,ALEJANDRO AGUAYO,FRANCISCO R High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
description	The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7% (59/74). When we considered histological type, we observed that p16 promoter methylation was significantly higher in squamous cell carcinomas (30/33, 91%) compared with adenocarcinomas (21/30, 70%) (p=0.029). In addition, no association between p16 promoter methylation and gender, age or smoking habit was found (p=0.202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independent
author	GUZMAN,LEDA M KORIYAMA,CHIHAYA AKIBA,SUMINORI EIZURU,YOSHITO CASTILLO,DARWINS CORVALAN,ALEJANDRO AGUAYO,FRANCISCO R
author_facet	GUZMAN,LEDA M KORIYAMA,CHIHAYA AKIBA,SUMINORI EIZURU,YOSHITO CASTILLO,DARWINS CORVALAN,ALEJANDRO AGUAYO,FRANCISCO R
author_sort	GUZMAN,LEDA M
title	High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
title_short	High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
title_full	High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
title_fullStr	High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
title_full_unstemmed	High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
title_sort	high frequency of p 16 promoter methylation in non-small cell lung carcinomas from chile
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400011
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High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile

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