Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences

Diffusion Magnetic Resonance Imaging provides images of unquestionable diagnostic value. It is commonly used in the assessment of stroke and in white matter fiber tracking, among other applications. The diffusion coefficient has been shown to depend on cell concentration, membrane permeability, and...

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Autores principales:	CHABERT,STEREN, SCIFO,PAOLA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	Diffusion Magnetic Resonance Imaging Interpretation non Gaussian
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500003
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spelling	oai:scielo:S0716-976020070005000032008-05-28Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in NeurosciencesCHABERT,STERENSCIFO,PAOLA Diffusion Magnetic Resonance Imaging Interpretation non Gaussian Diffusion Magnetic Resonance Imaging provides images of unquestionable diagnostic value. It is commonly used in the assessment of stroke and in white matter fiber tracking, among other applications. The diffusion coefficient has been shown to depend on cell concentration, membrane permeability, and cell orientation in the case of white matter or muscle fiber tracking; yet a clear relation between diffusion measurements and known physiological parameters is not established. The aim of this paper is to review hypotheses and actual knowledge on diffusion signal origin to provide assistance in the interpretation of diffusion MR images. Focus will be set on brain images, as most common applications of diffusion MRI are found in neuroradiology. Diffusion signal does not come from two intra- or extracellular compartments, as was first assumed. Restriction of water displacement due to membranes, hindrance in the extracellular space, and tissue heterogeneity are important factors. Unanswered questions remain on how to deal with tissue heterogeneity, and how to retrieve parameters less troublesome to work with from biological and clinical points of view. Diffusion quantification should be done with care, as many variables can lead to variation in measurementsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.4 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500003en10.4067/S0716-97602007000500003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Diffusion Magnetic Resonance Imaging Interpretation non Gaussian
spellingShingle	Diffusion Magnetic Resonance Imaging Interpretation non Gaussian CHABERT,STEREN SCIFO,PAOLA Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
description	Diffusion Magnetic Resonance Imaging provides images of unquestionable diagnostic value. It is commonly used in the assessment of stroke and in white matter fiber tracking, among other applications. The diffusion coefficient has been shown to depend on cell concentration, membrane permeability, and cell orientation in the case of white matter or muscle fiber tracking; yet a clear relation between diffusion measurements and known physiological parameters is not established. The aim of this paper is to review hypotheses and actual knowledge on diffusion signal origin to provide assistance in the interpretation of diffusion MR images. Focus will be set on brain images, as most common applications of diffusion MRI are found in neuroradiology. Diffusion signal does not come from two intra- or extracellular compartments, as was first assumed. Restriction of water displacement due to membranes, hindrance in the extracellular space, and tissue heterogeneity are important factors. Unanswered questions remain on how to deal with tissue heterogeneity, and how to retrieve parameters less troublesome to work with from biological and clinical points of view. Diffusion quantification should be done with care, as many variables can lead to variation in measurements
author	CHABERT,STEREN SCIFO,PAOLA
author_facet	CHABERT,STEREN SCIFO,PAOLA
author_sort	CHABERT,STEREN
title	Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
title_short	Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
title_full	Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
title_fullStr	Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
title_full_unstemmed	Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences
title_sort	diffusion signal in magnetic resonance imaging: origin and interpretation in neurosciences
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500003
work_keys_str_mv	AT chabertsteren diffusionsignalinmagneticresonanceimagingoriginandinterpretationinneurosciences AT scifopaola diffusionsignalinmagneticresonanceimagingoriginandinterpretationinneurosciences
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Diffusion Signal in Magnetic Resonance Imaging: Origin and Interpretation in Neurosciences

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