Complex, multifocal, individual-specific attention-related cortical functional circuits

Recent studies focusing on the analysis of individual patterns of non-sensory-motor CNS activity may significantly alter our view of CNS functional mapping. We have recently provided evidence for highly variable attention-related Slow Potential (SP) generating cortical areas across individuals (Basi...

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Autor principal:	BASILE,LUIS F. H.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	Attention cortical electrical activity high-resolution electroencephalography slow potentials source localization functional mapping
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500007
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spelling	oai:scielo:S0716-976020070005000072008-05-28Complex, multifocal, individual-specific attention-related cortical functional circuitsBASILE,LUIS F. H. Attention cortical electrical activity high-resolution electroencephalography slow potentials source localization functional mapping Recent studies focusing on the analysis of individual patterns of non-sensory-motor CNS activity may significantly alter our view of CNS functional mapping. We have recently provided evidence for highly variable attention-related Slow Potential (SP) generating cortical areas across individuals (Basile et al., 2003, 2006). In this work, we present new evidence, searching for other physiological indexes of attention by a new use of a well established method, for individual-specific sets of cortical areas active during expecting attention. We applied latency corrected peak averaging to oscillatory bursts, from 124-channel EEG recordings, and modeled their generators by current density reconstruction. We first computed event-related total power, and averaging was based on individual patterns of narrow task-induced band-power. This method is sensitive to activity out of synchrony with stimuli, and may detect task-related changes missed by regular Event-Related Potential (ERP) averaging. We additionally analyzed overall inter-electrode phase-coherence. The main results were (1) the detection of two bands of attention-induced beta range oscillations (around 25 and 21 Hz), whose scalp topography and current density cortical distribution were complex multi-focal, and highly variable across subjects, including prefrontal and posterior cortical areas. Most important, however, was the observation that (2) the generators of task-induced oscillations are largely the same individual-specific sets of cortical areas active during the resting, baseline state. We concluded that attention-related electrical cortical activity is highly individual-specific (significantly different from sensory-related visual evoked potentials or delta and theta induced band-power), and to a great extent already established during mere wakefulness. We discuss the critical implications of those results, in combination with other studies presenting individual data, to functional mapping: the need to abandon group averaging of task-related cortical activity and to revise studies on group averaged data, since the assumption of universal function to each cortical area appears deeply challenged. Clinical implications regard the interpretation of focal lesion consequences, functional reorganization, and neurosurgical planninginfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.4 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500007en10.4067/S0716-97602007000500007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Attention cortical electrical activity high-resolution electroencephalography slow potentials source localization functional mapping
spellingShingle	Attention cortical electrical activity high-resolution electroencephalography slow potentials source localization functional mapping BASILE,LUIS F. H. Complex, multifocal, individual-specific attention-related cortical functional circuits
description	Recent studies focusing on the analysis of individual patterns of non-sensory-motor CNS activity may significantly alter our view of CNS functional mapping. We have recently provided evidence for highly variable attention-related Slow Potential (SP) generating cortical areas across individuals (Basile et al., 2003, 2006). In this work, we present new evidence, searching for other physiological indexes of attention by a new use of a well established method, for individual-specific sets of cortical areas active during expecting attention. We applied latency corrected peak averaging to oscillatory bursts, from 124-channel EEG recordings, and modeled their generators by current density reconstruction. We first computed event-related total power, and averaging was based on individual patterns of narrow task-induced band-power. This method is sensitive to activity out of synchrony with stimuli, and may detect task-related changes missed by regular Event-Related Potential (ERP) averaging. We additionally analyzed overall inter-electrode phase-coherence. The main results were (1) the detection of two bands of attention-induced beta range oscillations (around 25 and 21 Hz), whose scalp topography and current density cortical distribution were complex multi-focal, and highly variable across subjects, including prefrontal and posterior cortical areas. Most important, however, was the observation that (2) the generators of task-induced oscillations are largely the same individual-specific sets of cortical areas active during the resting, baseline state. We concluded that attention-related electrical cortical activity is highly individual-specific (significantly different from sensory-related visual evoked potentials or delta and theta induced band-power), and to a great extent already established during mere wakefulness. We discuss the critical implications of those results, in combination with other studies presenting individual data, to functional mapping: the need to abandon group averaging of task-related cortical activity and to revise studies on group averaged data, since the assumption of universal function to each cortical area appears deeply challenged. Clinical implications regard the interpretation of focal lesion consequences, functional reorganization, and neurosurgical planning
author	BASILE,LUIS F. H.
author_facet	BASILE,LUIS F. H.
author_sort	BASILE,LUIS F. H.
title	Complex, multifocal, individual-specific attention-related cortical functional circuits
title_short	Complex, multifocal, individual-specific attention-related cortical functional circuits
title_full	Complex, multifocal, individual-specific attention-related cortical functional circuits
title_fullStr	Complex, multifocal, individual-specific attention-related cortical functional circuits
title_full_unstemmed	Complex, multifocal, individual-specific attention-related cortical functional circuits
title_sort	complex, multifocal, individual-specific attention-related cortical functional circuits
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000500007
work_keys_str_mv	AT basileluisfh complexmultifocalindividualspecificattentionrelatedcorticalfunctionalcircuits
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Complex, multifocal, individual-specific attention-related cortical functional circuits

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