Characterization of the long-terminal repeat single-strand tail-binding site of Moloney-MuLV integrase by crosslinking

Characterization of the long-terminal repeat single-strand tail-binding site of Moloney-MuLV integrase by crosslinking

Processing of viral DNA by retroviral integrase leaves a dinucleotide single-strand overhang in the unprocessed strand. Previous studies have stressed the importance of the 5' single-stranded (ss) tail in the integration process. To characterize the ss-tail binding site on M-MuLV integrase, we...

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Autores principales: VERA,JORGE, VALENZUELA,BEATRIZ, ROTH,MÓNICA J, LEÓN,ÓSCAR
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2008
Materias:
integrase
retrovirus
crosslinking
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100009
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