Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population

Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently...

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Autores principales:	BORASKA,VESNA, KRABI,VESELIN, IKE ULI,VEDRANA, BEI,KRISTIJAN, KAPITANOVI,SANJA, ZEMUNIK,TATIJANA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2008
Materias:	type 1 diabetes tumor necrosis factor gene (TNF) polymorphism genetic epidemiology Croatia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200005
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spelling	oai:scielo:S0716-976020080002000052009-03-24Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian populationBORASKA,VESNAKRABI,VESELINIKE ULI,VEDRANABEI,KRISTIJANKAPITANOVI,SANJAZEMUNIK,TATIJANA type 1 diabetes tumor necrosis factor gene (TNF) polymorphism genetic epidemiology Croatia Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the genetic association of TNF región with the disease has not been conclusive because of the strong linkage disequilibrium with HLA genes. In this study, we examined two TNF promoter variants (rs 1800629 at position -308, and rs361525 at position -238) for TIDM association in 233 patients and 144 controls from the population of South Croatia. A higher frequency of TNF -308 A alíele and also, a more frequent specific -308A -238G haplotype in TIDM patients were observed with a limited significance. However, we did not find strong evidence of association of TNF promoter polymorphisms with TIDM. In order to elucidate the trae contribution of TNF to TIDM susceptibility in our population, more comprehensive studies with HLA adjustment in a larger sample are required.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.41 n.2 20082008-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200005en10.4067/S0716-97602008000200005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	type 1 diabetes tumor necrosis factor gene (TNF) polymorphism genetic epidemiology Croatia
spellingShingle	type 1 diabetes tumor necrosis factor gene (TNF) polymorphism genetic epidemiology Croatia BORASKA,VESNA KRABI,VESELIN IKE ULI,VEDRANA BEI,KRISTIJAN KAPITANOVI,SANJA ZEMUNIK,TATIJANA Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
description	Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the genetic association of TNF región with the disease has not been conclusive because of the strong linkage disequilibrium with HLA genes. In this study, we examined two TNF promoter variants (rs 1800629 at position -308, and rs361525 at position -238) for TIDM association in 233 patients and 144 controls from the population of South Croatia. A higher frequency of TNF -308 A alíele and also, a more frequent specific -308A -238G haplotype in TIDM patients were observed with a limited significance. However, we did not find strong evidence of association of TNF promoter polymorphisms with TIDM. In order to elucidate the trae contribution of TNF to TIDM susceptibility in our population, more comprehensive studies with HLA adjustment in a larger sample are required.
author	BORASKA,VESNA KRABI,VESELIN IKE ULI,VEDRANA BEI,KRISTIJAN KAPITANOVI,SANJA ZEMUNIK,TATIJANA
author_facet	BORASKA,VESNA KRABI,VESELIN IKE ULI,VEDRANA BEI,KRISTIJAN KAPITANOVI,SANJA ZEMUNIK,TATIJANA
author_sort	BORASKA,VESNA
title	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
title_short	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
title_full	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
title_fullStr	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
title_full_unstemmed	Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population
title_sort	association of tnf promoter polymorphisms with type 1 diabetes in the south croatian population
publisher	Sociedad de Biología de Chile
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200005
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Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population

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