Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes

It has been proposed that differences in adipocyte function and/or metabolism between obese and lean individuáis may manifest themselves in functional adipose tissue abnormalities that lead to metabolic disorders in obesity. We studied lipogenesis and lipolysis of omental adipocytes from obese (OB)...

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Autores principales:	CIFUENTES,MARIANA, ALBALA,CECILIA, ROJAS,CECILIA V
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2008
Materias:	adipocyte cholesterol lipogenesis lipolysis obesity triglyceride metabolism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200009
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spelling	oai:scielo:S0716-976020080002000092009-03-24Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytesCIFUENTES,MARIANAALBALA,CECILIAROJAS,CECILIA V adipocyte cholesterol lipogenesis lipolysis obesity triglyceride metabolism It has been proposed that differences in adipocyte function and/or metabolism between obese and lean individuáis may manifest themselves in functional adipose tissue abnormalities that lead to metabolic disorders in obesity. We studied lipogenesis and lipolysis of omental adipocytes from obese (OB) and non-obese (NOB) humans. The specific activity of the lipogenic marker enzyme G3PDH was 50% lower in total adipocytes of OB compared to that of NOB subjects. Omental adipocytes from OB subjects also had lower basal lipolytic levéis, and a lower lipolytic response to p-adrenergic stimulus. Cholesterol depletion of adipocyte plasma membrane using methyl β-cyclodextrin caused a lipolytic effect on adipocytes of both groups together, but when obese and lean subjects were analyzed separately, the response was significant only in the obese. We present evidence of a different lipogenic and lipolytic profile in obese individuáis' omental adipocytes, and propose a relevant role of plasma membrane cholesterol, where the impact of its removal in OB and NOB adipocyte lipolysis differs.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.41 n.2 20082008-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200009en10.4067/S0716-97602008000200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	adipocyte cholesterol lipogenesis lipolysis obesity triglyceride metabolism
spellingShingle	adipocyte cholesterol lipogenesis lipolysis obesity triglyceride metabolism CIFUENTES,MARIANA ALBALA,CECILIA ROJAS,CECILIA V Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
description	It has been proposed that differences in adipocyte function and/or metabolism between obese and lean individuáis may manifest themselves in functional adipose tissue abnormalities that lead to metabolic disorders in obesity. We studied lipogenesis and lipolysis of omental adipocytes from obese (OB) and non-obese (NOB) humans. The specific activity of the lipogenic marker enzyme G3PDH was 50% lower in total adipocytes of OB compared to that of NOB subjects. Omental adipocytes from OB subjects also had lower basal lipolytic levéis, and a lower lipolytic response to p-adrenergic stimulus. Cholesterol depletion of adipocyte plasma membrane using methyl β-cyclodextrin caused a lipolytic effect on adipocytes of both groups together, but when obese and lean subjects were analyzed separately, the response was significant only in the obese. We present evidence of a different lipogenic and lipolytic profile in obese individuáis' omental adipocytes, and propose a relevant role of plasma membrane cholesterol, where the impact of its removal in OB and NOB adipocyte lipolysis differs.
author	CIFUENTES,MARIANA ALBALA,CECILIA ROJAS,CECILIA V
author_facet	CIFUENTES,MARIANA ALBALA,CECILIA ROJAS,CECILIA V
author_sort	CIFUENTES,MARIANA
title	Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
title_short	Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
title_full	Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
title_fullStr	Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
title_full_unstemmed	Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
title_sort	differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
publisher	Sociedad de Biología de Chile
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200009
work_keys_str_mv	AT cifuentesmariana differencesinlipogenesisandlipolysisinobeseandnonobeseadulthumanadipocytes AT albalacecilia differencesinlipogenesisandlipolysisinobeseandnonobeseadulthumanadipocytes AT rojasceciliav differencesinlipogenesisandlipolysisinobeseandnonobeseadulthumanadipocytes
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Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes

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