Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish

This work investigated the effect of the Hj receptor blockade in the forebrain of ablated Carassius auratus in a simple stimulus-response learning task using a T-maze test with positive reinforcement. The goldfish were submitted to surgery for removal of both telencephalic lobes five days before beg...

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Autores principales:	ROMAGUERA,FERNANDA, MATTIOLI,ROSANA
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2008
Materias:	histamine learning teleost fish telencephalon
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300010
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spelling	oai:scielo:S0716-976020080003000102009-04-23Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fishROMAGUERA,FERNANDAMATTIOLI,ROSANA histamine learning teleost fish telencephalon This work investigated the effect of the Hj receptor blockade in the forebrain of ablated Carassius auratus in a simple stimulus-response learning task using a T-maze test with positive reinforcement. The goldfish were submitted to surgery for removal of both telencephalic lobes five days before beginning the experiment. A T-shaped glass aquarium was employed, with two feeders located at the extremities of the long arm. One of the two feeders was blocked. The experimental triáis were performed in nine consecutive days. Each fish was individually placed in the short arm and confined there for thirty seconds, then it was allowed to swim through the aquarium to search for food for ten minutes (máximum period). Time to find food was analysed in seconds. Animáis were injected intraperitoneally with chlorpheniramine (CPA) at 16 mg/kg of body weight or saline after every trial, ten minutes after being placed back in the home aquarium. The results show that all the training latencies of the A-SAL group were higher than the latencies of the S-SAL group. The S-SAL group had decreased latencies from the second trial on, while the S-CPA group showed decreased latencies after the fourth trial. The A-SAL group showed reduced latencies after the fifth trial, but the A-CPA group mainteined the latencies throughout the experiment. This suggests that CPA impairs the consolidation of learning both on telencephalon ablated animáis and in sham-operated ones through its action on mesencephalic structures of the brain and/or on the cerebellum in teleost fish.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.41 n.3 20082008-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300010en10.4067/S0716-97602008000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	histamine learning teleost fish telencephalon
spellingShingle	histamine learning teleost fish telencephalon ROMAGUERA,FERNANDA MATTIOLI,ROSANA Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
description	This work investigated the effect of the Hj receptor blockade in the forebrain of ablated Carassius auratus in a simple stimulus-response learning task using a T-maze test with positive reinforcement. The goldfish were submitted to surgery for removal of both telencephalic lobes five days before beginning the experiment. A T-shaped glass aquarium was employed, with two feeders located at the extremities of the long arm. One of the two feeders was blocked. The experimental triáis were performed in nine consecutive days. Each fish was individually placed in the short arm and confined there for thirty seconds, then it was allowed to swim through the aquarium to search for food for ten minutes (máximum period). Time to find food was analysed in seconds. Animáis were injected intraperitoneally with chlorpheniramine (CPA) at 16 mg/kg of body weight or saline after every trial, ten minutes after being placed back in the home aquarium. The results show that all the training latencies of the A-SAL group were higher than the latencies of the S-SAL group. The S-SAL group had decreased latencies from the second trial on, while the S-CPA group showed decreased latencies after the fourth trial. The A-SAL group showed reduced latencies after the fifth trial, but the A-CPA group mainteined the latencies throughout the experiment. This suggests that CPA impairs the consolidation of learning both on telencephalon ablated animáis and in sham-operated ones through its action on mesencephalic structures of the brain and/or on the cerebellum in teleost fish.
author	ROMAGUERA,FERNANDA MATTIOLI,ROSANA
author_facet	ROMAGUERA,FERNANDA MATTIOLI,ROSANA
author_sort	ROMAGUERA,FERNANDA
title	Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
title_short	Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
title_full	Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
title_fullStr	Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
title_full_unstemmed	Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
title_sort	chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish
publisher	Sociedad de Biología de Chile
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300010
work_keys_str_mv	AT romaguerafernanda chlorpheniramineimpairsspatialchoicelearningintelencephalonablatedfish AT mattiolirosana chlorpheniramineimpairsspatialchoicelearningintelencephalonablatedfish
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Chlorpheniramine impairs spatial choice learning in telencephalon-ablated fish

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