The possible role of Myosin light chain in myoblast proliferation

Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle con...

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Autores principales:	ZHANG,SU-ZHEN, XU,YONG, XIE,HUI-QI, LI,XIU-QUN, WEI,YU-QUAN, YANG,ZHI-MING
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2009
Materias:	Myosin light chain Proliferation Myoblast Extraocular muscle
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100013
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spelling	oai:scielo:S0716-976020090001000132009-06-11The possible role of Myosin light chain in myoblast proliferationZHANG,SU-ZHENXU,YONGXIE,HUI-QILI,XIU-QUNWEI,YU-QUANYANG,ZHI-MING Myosin light chain Proliferation Myoblast Extraocular muscle Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this report, we studied the possible role of Myl in the proliferation of skeletal muscle-derived myoblasts. Compared to diaphragm-derived myoblasts, the extraocular muscle-derived myoblasts with lower levels of Myl proliferated faster, maintained a longer proliferation phase, and formed more final myotubes. It was found that blockading Myl with anti-Myl antibody or knockdown of Myll by siRNA targeted against Myll could enhance the myoblast proliferation and delay the differentiation of myoblasts. Our results suggested that Myl, likely Myll, can negatively affect myoblast proliferation by facilitating myoblast withdrawal from cell cycle and differentiation.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.42 n.1 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100013en10.4067/S0716-97602009000100013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Myosin light chain Proliferation Myoblast Extraocular muscle
spellingShingle	Myosin light chain Proliferation Myoblast Extraocular muscle ZHANG,SU-ZHEN XU,YONG XIE,HUI-QI LI,XIU-QUN WEI,YU-QUAN YANG,ZHI-MING The possible role of Myosin light chain in myoblast proliferation
description	Skeletal muscles have the potential to regenerate by activation of quiescent satellite cells, however, the molecular signature that governs satellite cells during muscle regeneration is not well defined. Myosin light chains (Myls) are sarcomere-related proteins as traditional regulator of muscle contraction. In this report, we studied the possible role of Myl in the proliferation of skeletal muscle-derived myoblasts. Compared to diaphragm-derived myoblasts, the extraocular muscle-derived myoblasts with lower levels of Myl proliferated faster, maintained a longer proliferation phase, and formed more final myotubes. It was found that blockading Myl with anti-Myl antibody or knockdown of Myll by siRNA targeted against Myll could enhance the myoblast proliferation and delay the differentiation of myoblasts. Our results suggested that Myl, likely Myll, can negatively affect myoblast proliferation by facilitating myoblast withdrawal from cell cycle and differentiation.
author	ZHANG,SU-ZHEN XU,YONG XIE,HUI-QI LI,XIU-QUN WEI,YU-QUAN YANG,ZHI-MING
author_facet	ZHANG,SU-ZHEN XU,YONG XIE,HUI-QI LI,XIU-QUN WEI,YU-QUAN YANG,ZHI-MING
author_sort	ZHANG,SU-ZHEN
title	The possible role of Myosin light chain in myoblast proliferation
title_short	The possible role of Myosin light chain in myoblast proliferation
title_full	The possible role of Myosin light chain in myoblast proliferation
title_fullStr	The possible role of Myosin light chain in myoblast proliferation
title_full_unstemmed	The possible role of Myosin light chain in myoblast proliferation
title_sort	possible role of myosin light chain in myoblast proliferation
publisher	Sociedad de Biología de Chile
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100013
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The possible role of Myosin light chain in myoblast proliferation

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