Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats

Some selenium compounds offer important health benefits when administered at supranutritional doses, such as improvement of the immune system and of male fertility, and the prevention of some types of cancer. The traditional selenium indexes do not account for the metabolic status of this element am...

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Autores principales:	MAHN,ANDREA V, TOLEDO,HÉCTOR M, RUZ,MANUEL H
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2009
Materias:	selenium status protein abundance rat blood plasma nutritional biomarkers
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000200004
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spelling	oai:scielo:S0716-976020090002000042009-10-09Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of ratsMAHN,ANDREA VTOLEDO,HÉCTOR MRUZ,MANUEL H selenium status protein abundance rat blood plasma nutritional biomarkers Some selenium compounds offer important health benefits when administered at supranutritional doses, such as improvement of the immune system and of male fertility, and the prevention of some types of cancer. The traditional selenium indexes do not account for the metabolic status of this element among replete individuals. As a consequence, there is a need for new indexes that distinguish between repletion statuses of selenium. The aim of this work was to indentify some plasmatic proteins that respond to supranutritional doses of selenium, which could be proposed as new protein markers of selenium intake. The effect on rats of dietary supplementation with either selenomethylselenocysteine (SMSeC) or sodium-selenate on some blood plasma proteins was investigated. Two experimental groups consisting of six rats each were fed a basic diet supplemented with either SMSeC or sodium-selenate at 1.9 mg-Se / g-diet for ten weeks. The control group was fed a diet that contained the recommended selenium dose (0.15 mg-Se / g-diet). The changes in the abundance of a group of plasmatic proteins were quantified and analysed statistically. Haptoglobin, apolipoprotein E and transthyretin increased their abundance after diet supplementation with either form of selenium. HNF6 was responsive only to SMSeC, whereas fibrinogen responded only to sodium-selenate. We postulate that the protein patterns observed in this work could be proposed as new molecular biology-based markers of selenium intake.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.42 n.2 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000200004en10.4067/S0716-97602009000200004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	selenium status protein abundance rat blood plasma nutritional biomarkers
spellingShingle	selenium status protein abundance rat blood plasma nutritional biomarkers MAHN,ANDREA V TOLEDO,HÉCTOR M RUZ,MANUEL H Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
description	Some selenium compounds offer important health benefits when administered at supranutritional doses, such as improvement of the immune system and of male fertility, and the prevention of some types of cancer. The traditional selenium indexes do not account for the metabolic status of this element among replete individuals. As a consequence, there is a need for new indexes that distinguish between repletion statuses of selenium. The aim of this work was to indentify some plasmatic proteins that respond to supranutritional doses of selenium, which could be proposed as new protein markers of selenium intake. The effect on rats of dietary supplementation with either selenomethylselenocysteine (SMSeC) or sodium-selenate on some blood plasma proteins was investigated. Two experimental groups consisting of six rats each were fed a basic diet supplemented with either SMSeC or sodium-selenate at 1.9 mg-Se / g-diet for ten weeks. The control group was fed a diet that contained the recommended selenium dose (0.15 mg-Se / g-diet). The changes in the abundance of a group of plasmatic proteins were quantified and analysed statistically. Haptoglobin, apolipoprotein E and transthyretin increased their abundance after diet supplementation with either form of selenium. HNF6 was responsive only to SMSeC, whereas fibrinogen responded only to sodium-selenate. We postulate that the protein patterns observed in this work could be proposed as new molecular biology-based markers of selenium intake.
author	MAHN,ANDREA V TOLEDO,HÉCTOR M RUZ,MANUEL H
author_facet	MAHN,ANDREA V TOLEDO,HÉCTOR M RUZ,MANUEL H
author_sort	MAHN,ANDREA V
title	Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
title_short	Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
title_full	Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
title_fullStr	Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
title_full_unstemmed	Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
title_sort	organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats
publisher	Sociedad de Biología de Chile
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000200004
work_keys_str_mv	AT mahnandreav organicandinorganicseleniumcompoundsproducedifferentproteinpatternsinthebloodplasmaofrats AT toledohectorm organicandinorganicseleniumcompoundsproducedifferentproteinpatternsinthebloodplasmaofrats AT ruzmanuelh organicandinorganicseleniumcompoundsproducedifferentproteinpatternsinthebloodplasmaofrats
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Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats

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