Nkx-2.3 gene in mouse epidemial maturation

In higher vertebrates, from amphibians to humans, epidemial maturation is a conserved developmental process. Using adult epidemial tissue and an established keratinocyte cell line, the mouse Nkx-2.3 homeobox gene was demonstrated, for the first time, to be expressed in mouse epidermal keratinocytes....

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Autor principal:	MA,CHANG M
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2009
Materias:	Nkx-2.3 epidermis homeobox gene skin maturation differentiation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300001
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spelling	oai:scielo:S0716-976020090003000012009-11-02Nkx-2.3 gene in mouse epidemial maturationMA,CHANG M Nkx-2.3 epidermis homeobox gene skin maturation differentiation In higher vertebrates, from amphibians to humans, epidemial maturation is a conserved developmental process. Using adult epidemial tissue and an established keratinocyte cell line, the mouse Nkx-2.3 homeobox gene was demonstrated, for the first time, to be expressed in mouse epidermal keratinocytes. Under the normal culture condition, the spontaneous aggregation phenomenon, a common initiation step of ES cell differentiation, and the induction of mouse adult K1 keratin, a marker of mature epidermal keratinocytes, were both observed in vitro when the Xenopus Nkx-2.3 gene was stably transfected into a mouse pluripotent P19 EC cell line. The induction of mouse K1 keratin by using its Xenopus orthologous gene in the mouse P19 cell implies that Nkx-2.3 may play a conserved role in the epidermal maturation of the mouse, as it does in that of the frog (Ma, 2004). However, the CAT assay study on frog adult keratin promoter could not find the induction of adult keratin. This implies there might not be a direct activation of its promoter.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.42 n.3 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300001en10.4067/S0716-97602009000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nkx-2.3 epidermis homeobox gene skin maturation differentiation
spellingShingle	Nkx-2.3 epidermis homeobox gene skin maturation differentiation MA,CHANG M Nkx-2.3 gene in mouse epidemial maturation
description	In higher vertebrates, from amphibians to humans, epidemial maturation is a conserved developmental process. Using adult epidemial tissue and an established keratinocyte cell line, the mouse Nkx-2.3 homeobox gene was demonstrated, for the first time, to be expressed in mouse epidermal keratinocytes. Under the normal culture condition, the spontaneous aggregation phenomenon, a common initiation step of ES cell differentiation, and the induction of mouse adult K1 keratin, a marker of mature epidermal keratinocytes, were both observed in vitro when the Xenopus Nkx-2.3 gene was stably transfected into a mouse pluripotent P19 EC cell line. The induction of mouse K1 keratin by using its Xenopus orthologous gene in the mouse P19 cell implies that Nkx-2.3 may play a conserved role in the epidermal maturation of the mouse, as it does in that of the frog (Ma, 2004). However, the CAT assay study on frog adult keratin promoter could not find the induction of adult keratin. This implies there might not be a direct activation of its promoter.
author	MA,CHANG M
author_facet	MA,CHANG M
author_sort	MA,CHANG M
title	Nkx-2.3 gene in mouse epidemial maturation
title_short	Nkx-2.3 gene in mouse epidemial maturation
title_full	Nkx-2.3 gene in mouse epidemial maturation
title_fullStr	Nkx-2.3 gene in mouse epidemial maturation
title_full_unstemmed	Nkx-2.3 gene in mouse epidemial maturation
title_sort	nkx-2.3 gene in mouse epidemial maturation
publisher	Sociedad de Biología de Chile
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300001
work_keys_str_mv	AT machangm nkx23geneinmouseepidemialmaturation
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Nkx-2.3 gene in mouse epidemial maturation

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