Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind plac...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2009
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300002 |
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oai:scielo:S0716-976020090003000022009-11-02Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomniaBRANDÃO,LETÍCIA CHACHUL,HELENABITTENCOURT,LIA RBARACAT,EDMUND CTUFIK,SERGIOD'ALMEIDA,VÂNIA homocysteine isoflavones insomnia menopause oxidative stress Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.42 n.3 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300002en10.4067/S0716-97602009000300002 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
homocysteine isoflavones insomnia menopause oxidative stress |
| spellingShingle |
homocysteine isoflavones insomnia menopause oxidative stress BRANDÃO,LETÍCIA C HACHUL,HELENA BITTENCOURT,LIA R BARACAT,EDMUND C TUFIK,SERGIO D'ALMEIDA,VÂNIA Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| description |
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations. |
| author |
BRANDÃO,LETÍCIA C HACHUL,HELENA BITTENCOURT,LIA R BARACAT,EDMUND C TUFIK,SERGIO D'ALMEIDA,VÂNIA |
| author_facet |
BRANDÃO,LETÍCIA C HACHUL,HELENA BITTENCOURT,LIA R BARACAT,EDMUND C TUFIK,SERGIO D'ALMEIDA,VÂNIA |
| author_sort |
BRANDÃO,LETÍCIA C |
| title |
Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| title_short |
Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| title_full |
Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| title_fullStr |
Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| title_full_unstemmed |
Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| title_sort |
effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2009 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300002 |
| work_keys_str_mv |
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