Effect of crocus sativus on gentamicin induced nephrotoxicity

Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g)...

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Autores principales:	AJAMI,MARJAN, EGHTESADI,SHAHRIAR, PAZOKI-TOROUDI,HAMIDREZA, HABIBEY,ROUHOLLAH, EBRAHIMI,SOLTAN AHMED
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	Saffron Malondialdehyde (MDA) aminoglycoside renal failure
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100010
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spelling	oai:scielo:S0716-976020100001000102010-05-07Effect of crocus sativus on gentamicin induced nephrotoxicityAJAMI,MARJANEGHTESADI,SHAHRIARPAZOKI-TOROUDI,HAMIDREZAHABIBEY,ROUHOLLAHEBRAHIMI,SOLTAN AHMED Saffron Malondialdehyde (MDA) aminoglycoside renal failure Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100010en10.4067/S0716-97602010000100010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Saffron Malondialdehyde (MDA) aminoglycoside renal failure
spellingShingle	Saffron Malondialdehyde (MDA) aminoglycoside renal failure AJAMI,MARJAN EGHTESADI,SHAHRIAR PAZOKI-TOROUDI,HAMIDREZA HABIBEY,ROUHOLLAH EBRAHIMI,SOLTAN AHMED Effect of crocus sativus on gentamicin induced nephrotoxicity
description	Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced severe histological changes. Saffron at 40 mg/k/d significantly reduced gentamicin-induced increases in BUN and histological scores (p<0.05). Gentamicin-induced increases in BUN, SCr and MDA and histological injury were significantly reduced by treatment with saffron 80 mg/k/d (p<0.05, p<0.001, p<0.05, and p<0.001 respectively). In conclusion, our results suggest that saffron treatment reduces gentamicin-induced nephrotoxicity and this effect seems to be dose dependent.
author	AJAMI,MARJAN EGHTESADI,SHAHRIAR PAZOKI-TOROUDI,HAMIDREZA HABIBEY,ROUHOLLAH EBRAHIMI,SOLTAN AHMED
author_facet	AJAMI,MARJAN EGHTESADI,SHAHRIAR PAZOKI-TOROUDI,HAMIDREZA HABIBEY,ROUHOLLAH EBRAHIMI,SOLTAN AHMED
author_sort	AJAMI,MARJAN
title	Effect of crocus sativus on gentamicin induced nephrotoxicity
title_short	Effect of crocus sativus on gentamicin induced nephrotoxicity
title_full	Effect of crocus sativus on gentamicin induced nephrotoxicity
title_fullStr	Effect of crocus sativus on gentamicin induced nephrotoxicity
title_full_unstemmed	Effect of crocus sativus on gentamicin induced nephrotoxicity
title_sort	effect of crocus sativus on gentamicin induced nephrotoxicity
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100010
work_keys_str_mv	AT ajamimarjan effectofcrocussativusongentamicininducednephrotoxicity AT eghtesadishahriar effectofcrocussativusongentamicininducednephrotoxicity AT pazokitoroudihamidreza effectofcrocussativusongentamicininducednephrotoxicity AT habibeyrouhollah effectofcrocussativusongentamicininducednephrotoxicity AT ebrahimisoltanahmed effectofcrocussativusongentamicininducednephrotoxicity
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Effect of crocus sativus on gentamicin induced nephrotoxicity

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