Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats

Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethyln...

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Autores principales:	PRADEEP,KANNAMPALLI, RAJ MOHAN,CHANDRASEKARAN VICTOR, GOBIANAND,KUPANNAN, KARTHIKEYAN,SIVANESAN
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	antioxidants Cassia fistula diethylnitrosamine hepatoprotective lipid peroxidation silymarin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100013
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spelling	oai:scielo:S0716-976020100001000132010-05-07Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated ratsPRADEEP,KANNAMPALLIRAJ MOHAN,CHANDRASEKARAN VICTORGOBIANAND,KUPANNANKARTHIKEYAN,SIVANESAN antioxidants Cassia fistula diethylnitrosamine hepatoprotective lipid peroxidation silymarin Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethylnitrosamine induced liver injury in ethanol pretreated rats. Albino Wistar rats, pretreated with ethanol for 15 days, were administered a single dose of DEN. Thirty days after DEN administration, hepatotocellular damage was observed histologically, along with elevated levels of serum AST, ALT, ALP, LDH, γ-GT and bilirubin and a simultaneous fall in the levels of the marker enzymes in the liver tissue. Liver oxidative stress was confirmed by elevated levels of lipid peroxidation (LPO) and a decrease in enzymic and non-enzymic antioxidants activities. Oral administration of the ethanolic leaf extract (ELE) of Cassia fistula for 30 days to ethanol + DEN treated rats significantly improved the above alterations in the markers of hepatotoxicity and oxidative stress, resulting in the reversal of most of the parameters studied and were comparable to the standard hepatoprotective drug silymarin.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100013en10.4067/S0716-97602010000100013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidants Cassia fistula diethylnitrosamine hepatoprotective lipid peroxidation silymarin
spellingShingle	antioxidants Cassia fistula diethylnitrosamine hepatoprotective lipid peroxidation silymarin PRADEEP,KANNAMPALLI RAJ MOHAN,CHANDRASEKARAN VICTOR GOBIANAND,KUPANNAN KARTHIKEYAN,SIVANESAN Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
description	Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethylnitrosamine induced liver injury in ethanol pretreated rats. Albino Wistar rats, pretreated with ethanol for 15 days, were administered a single dose of DEN. Thirty days after DEN administration, hepatotocellular damage was observed histologically, along with elevated levels of serum AST, ALT, ALP, LDH, γ-GT and bilirubin and a simultaneous fall in the levels of the marker enzymes in the liver tissue. Liver oxidative stress was confirmed by elevated levels of lipid peroxidation (LPO) and a decrease in enzymic and non-enzymic antioxidants activities. Oral administration of the ethanolic leaf extract (ELE) of Cassia fistula for 30 days to ethanol + DEN treated rats significantly improved the above alterations in the markers of hepatotoxicity and oxidative stress, resulting in the reversal of most of the parameters studied and were comparable to the standard hepatoprotective drug silymarin.
author	PRADEEP,KANNAMPALLI RAJ MOHAN,CHANDRASEKARAN VICTOR GOBIANAND,KUPANNAN KARTHIKEYAN,SIVANESAN
author_facet	PRADEEP,KANNAMPALLI RAJ MOHAN,CHANDRASEKARAN VICTOR GOBIANAND,KUPANNAN KARTHIKEYAN,SIVANESAN
author_sort	PRADEEP,KANNAMPALLI
title	Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
title_short	Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
title_full	Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
title_fullStr	Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
title_full_unstemmed	Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
title_sort	protective effect of cassia fistula linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100013
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Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats

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