In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures

Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientale, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties. So far no scientifc evidence has been found in a literature survey regarding the g...

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Autores principales:	Erolu,Erhan H, Hamzaolu,Ergin, Aksoy,Ahmet, Budak,Ümit, Özkul,Yusuf
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	genotoxic Helichrysum micronucleus mitotic index replication index
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200005
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spelling	oai:scielo:S0716-976020100002000052010-09-24In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes CulturesErolu,Erhan HHamzaolu,ErginAksoy,AhmetBudak,ÜmitÖzkul,Yusuf genotoxic Helichrysum micronucleus mitotic index replication index Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientale, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties. So far no scientifc evidence has been found in a literature survey regarding the genotoxic effects of these plants. This work evaluated the genotoxic effects on human lymphocyte cultures induced by methanol extracts of these plants, assayed in different concentrations (0.01, 0.05, 0.1, 0.5 and 1 mg/mL). According to the results, Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum induced the formation of micronuclei and decreased the mitotic and replication indexes. Helichrysum orientale did not affect these parameters, whereas Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum were clearly genotoxic. They should therefore not be used freely in alternative medicine, although their antiproliferative activity may suggest antimitotic and anticarcinogenic properties. Helichrysum orientale could be used in alternative medicine.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.2 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200005en10.4067/S0716-97602010000200005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	genotoxic Helichrysum micronucleus mitotic index replication index
spellingShingle	genotoxic Helichrysum micronucleus mitotic index replication index Erolu,Erhan H Hamzaolu,Ergin Aksoy,Ahmet Budak,Ümit Özkul,Yusuf In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
description	Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientale, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties. So far no scientifc evidence has been found in a literature survey regarding the genotoxic effects of these plants. This work evaluated the genotoxic effects on human lymphocyte cultures induced by methanol extracts of these plants, assayed in different concentrations (0.01, 0.05, 0.1, 0.5 and 1 mg/mL). According to the results, Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum induced the formation of micronuclei and decreased the mitotic and replication indexes. Helichrysum orientale did not affect these parameters, whereas Helichrysum noeanum, Helichrysum pamphylicum and Helichrysum sanguineum were clearly genotoxic. They should therefore not be used freely in alternative medicine, although their antiproliferative activity may suggest antimitotic and anticarcinogenic properties. Helichrysum orientale could be used in alternative medicine.
author	Erolu,Erhan H Hamzaolu,Ergin Aksoy,Ahmet Budak,Ümit Özkul,Yusuf
author_facet	Erolu,Erhan H Hamzaolu,Ergin Aksoy,Ahmet Budak,Ümit Özkul,Yusuf
author_sort	Erolu,Erhan H
title	In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
title_short	In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
title_full	In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
title_fullStr	In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
title_full_unstemmed	In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
title_sort	in vitro genotoxic effects of four helichrysum species in human lymphocytes cultures
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200005
work_keys_str_mv	AT eroluerhanh invitrogenotoxiceffectsoffourhelichrysumspeciesinhumanlymphocytescultures AT hamzaoluergin invitrogenotoxiceffectsoffourhelichrysumspeciesinhumanlymphocytescultures AT aksoyahmet invitrogenotoxiceffectsoffourhelichrysumspeciesinhumanlymphocytescultures AT budakumit invitrogenotoxiceffectsoffourhelichrysumspeciesinhumanlymphocytescultures AT ozkulyusuf invitrogenotoxiceffectsoffourhelichrysumspeciesinhumanlymphocytescultures
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In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures

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