Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats

Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF...

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Autores principales:	Muñoz,Pablo C, Aspé,Mauricio A, Contreras,Luis S, Palacios,Adrián G
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	DNA methylation recognition memory synaptic plasticity hippocampal perirhinal cortex BDNF
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200013
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spelling	oai:scielo:S0716-976020100002000132010-09-24Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in ratsMuñoz,Pablo CAspé,Mauricio AContreras,Luis SPalacios,Adrián G DNA methylation recognition memory synaptic plasticity hippocampal perirhinal cortex BDNF Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF) for recognition memory has already been recognized. Recent evidence suggests that DNA methylation regulates the expression of BDNF and memory. Behavioral and molecular approaches were used to understand the potential contribution of DNA methylation to recognition memory. To that end, rats were tested for their ability to distinguish novel from familiar objects by using a spontaneous object recognition task. Furthermore, the level of DNA methylation was estimated after trials with a methyl-sensitive PCR. We found a signifcant correlation between performance on the novel object task and the expression of BDNF, negatively in hippocampal slices and positively in perirhinal cortical slices. By contrast, methylation of DNA in CpG island 1 in the promoter of exon 1 in BDNF only correlated in hippocampal slices, but not in the Pxc cortical slices from trained animals. These results suggest that DNA methylation may be involved in the regulation of the BDNF gene during recognition memory, at least in the hippocampus.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.2 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200013en10.4067/S0716-97602010000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	DNA methylation recognition memory synaptic plasticity hippocampal perirhinal cortex BDNF
spellingShingle	DNA methylation recognition memory synaptic plasticity hippocampal perirhinal cortex BDNF Muñoz,Pablo C Aspé,Mauricio A Contreras,Luis S Palacios,Adrián G Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
description	Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF) for recognition memory has already been recognized. Recent evidence suggests that DNA methylation regulates the expression of BDNF and memory. Behavioral and molecular approaches were used to understand the potential contribution of DNA methylation to recognition memory. To that end, rats were tested for their ability to distinguish novel from familiar objects by using a spontaneous object recognition task. Furthermore, the level of DNA methylation was estimated after trials with a methyl-sensitive PCR. We found a signifcant correlation between performance on the novel object task and the expression of BDNF, negatively in hippocampal slices and positively in perirhinal cortical slices. By contrast, methylation of DNA in CpG island 1 in the promoter of exon 1 in BDNF only correlated in hippocampal slices, but not in the Pxc cortical slices from trained animals. These results suggest that DNA methylation may be involved in the regulation of the BDNF gene during recognition memory, at least in the hippocampus.
author	Muñoz,Pablo C Aspé,Mauricio A Contreras,Luis S Palacios,Adrián G
author_facet	Muñoz,Pablo C Aspé,Mauricio A Contreras,Luis S Palacios,Adrián G
author_sort	Muñoz,Pablo C
title	Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
title_short	Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
title_full	Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
title_fullStr	Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
title_full_unstemmed	Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
title_sort	correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200013
work_keys_str_mv	AT munozpabloc correlationsofrecognitionmemoryperformancewithexpressionandmethylationofbrainderivedneurotrophicfactorinrats AT aspemauricioa correlationsofrecognitionmemoryperformancewithexpressionandmethylationofbrainderivedneurotrophicfactorinrats AT contrerasluiss correlationsofrecognitionmemoryperformancewithexpressionandmethylationofbrainderivedneurotrophicfactorinrats AT palaciosadriang correlationsofrecognitionmemoryperformancewithexpressionandmethylationofbrainderivedneurotrophicfactorinrats
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Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats

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