Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)

Congenital Chagas disease acquired special importance in Chile after the certification of the control of Triatoma infestans and transmission by blood donors affected with Trypanosoma cruzi. In order to establish adequate protocols for intervention and control in infected mother-neonate pairs in ende...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Apt,Werner, Zulantay,Inés, Solari,Aldo, Ortiz,Sylvia, Oddo,David, Corral,Gabriela, Truyens,Carine, Carlier,Yves
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	Congenital Chagas disease Province of Choapa multidisciplinary study
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300002
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602010000300002
record_format	dspace
spelling	oai:scielo:S0716-976020100003000022010-11-30Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)Apt,WernerZulantay,InésSolari,AldoOrtiz,SylviaOddo,DavidCorral,GabrielaTruyens,CarineCarlier,Yves Congenital Chagas disease Province of Choapa multidisciplinary study Congenital Chagas disease acquired special importance in Chile after the certification of the control of Triatoma infestans and transmission by blood donors affected with Trypanosoma cruzi. In order to establish adequate protocols for intervention and control in infected mother-neonate pairs in endemic zones of Chagas disease, we present partial results (2005-2008) of a pilot project which is being carried out in the Province of Choapa, IV Region, Chile, whose objectives are: determine the current prevalence of the disease in pregnant women, estimate the incidence of vertical transmission of T. cruzi to newborns, determine the lineages of the parasite present in mothers who do and do not transmit the disease, determine the prevalence of Chagas disease in maternal grandmothers of neonates and study placental histopathology. Preliminary results indicated that in this study period, 3.7% of the women who gave birth in the Province have Chagas disease and 2.5% of their newborns were infected. The most frequent T. cruzi genotypes found in mothers studied during pregnancy were TCI and TCIId, either alone or in mixed infections. A high percentage (74.3%) of the grandmothers studied was infected with the parasite. In 29 placentas from mothers with Chagas disease we observed edema, necrosis, fibrinoid deposits and slight lymphoplasmocyte infiltration. In three placentas we found erythroblastosis and in one of them amastigote forms of T. cruzi; this was one of the cases of congenital infection. The evaluation of the diagnostic and control protocols generated will allow us to determine if it has been possible to modify the natural history of vertical transmission of T. cruzi in Chile.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300002en10.4067/S0716-97602010000300002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Congenital Chagas disease Province of Choapa multidisciplinary study
spellingShingle	Congenital Chagas disease Province of Choapa multidisciplinary study Apt,Werner Zulantay,Inés Solari,Aldo Ortiz,Sylvia Oddo,David Corral,Gabriela Truyens,Carine Carlier,Yves Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
description	Congenital Chagas disease acquired special importance in Chile after the certification of the control of Triatoma infestans and transmission by blood donors affected with Trypanosoma cruzi. In order to establish adequate protocols for intervention and control in infected mother-neonate pairs in endemic zones of Chagas disease, we present partial results (2005-2008) of a pilot project which is being carried out in the Province of Choapa, IV Region, Chile, whose objectives are: determine the current prevalence of the disease in pregnant women, estimate the incidence of vertical transmission of T. cruzi to newborns, determine the lineages of the parasite present in mothers who do and do not transmit the disease, determine the prevalence of Chagas disease in maternal grandmothers of neonates and study placental histopathology. Preliminary results indicated that in this study period, 3.7% of the women who gave birth in the Province have Chagas disease and 2.5% of their newborns were infected. The most frequent T. cruzi genotypes found in mothers studied during pregnancy were TCI and TCIId, either alone or in mixed infections. A high percentage (74.3%) of the grandmothers studied was infected with the parasite. In 29 placentas from mothers with Chagas disease we observed edema, necrosis, fibrinoid deposits and slight lymphoplasmocyte infiltration. In three placentas we found erythroblastosis and in one of them amastigote forms of T. cruzi; this was one of the cases of congenital infection. The evaluation of the diagnostic and control protocols generated will allow us to determine if it has been possible to modify the natural history of vertical transmission of T. cruzi in Chile.
author	Apt,Werner Zulantay,Inés Solari,Aldo Ortiz,Sylvia Oddo,David Corral,Gabriela Truyens,Carine Carlier,Yves
author_facet	Apt,Werner Zulantay,Inés Solari,Aldo Ortiz,Sylvia Oddo,David Corral,Gabriela Truyens,Carine Carlier,Yves
author_sort	Apt,Werner
title	Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
title_short	Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
title_full	Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
title_fullStr	Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
title_full_unstemmed	Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)
title_sort	vertical transmission of trypanosoma cruzi in the province of choapa, iv region, chile: preliminary report (2005-2008)
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300002
work_keys_str_mv	AT aptwerner verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT zulantayines verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT solarialdo verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT ortizsylvia verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT oddodavid verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT corralgabriela verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT truyenscarine verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008 AT carlieryves verticaltransmissionoftrypanosomacruziintheprovinceofchoapaivregionchilepreliminaryreport20052008
_version_	1718441462341828608

Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile: Preliminary Report (2005-2008)

Ejemplares similares