Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal

Chagas' disease is produced by the haemophlagelated protozoan Trypanosoma cruzi and transmitted by haematophages insects such as Triatoma infestans (vinchuca). Due to vector control, congenital transmission gains importance and is responsible for the presence and expansion of this disease in no...

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Autores principales:	Kemmerling,Ulrike, Bosco,Cleo, Galanti,Norbel
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	congenital Chagas' disease mechanism of infection tissue invasion
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300007
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spelling	oai:scielo:S0716-976020100003000072010-11-30Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposalKemmerling,UlrikeBosco,CleoGalanti,Norbel congenital Chagas' disease mechanism of infection tissue invasion Chagas' disease is produced by the haemophlagelated protozoan Trypanosoma cruzi and transmitted by haematophages insects such as Triatoma infestans (vinchuca). Due to vector control, congenital transmission gains importance and is responsible for the presence and expansion of this disease in non-endemic areas. The mechanisms of congenital infection are uncertain. It has been suggested that the parasite reaches the fetus through the bloodstream by crossing the placental barrier, and that congenital Chagas' disease is the result of complex interactions between the immune response, placental factors, and the parasite's characteristics. We review the cellular and molecular mechanisms of infection and invasion of the parasite and how immune and placental factors may modulate this process. Finally, we propose a possible model for the vertical transmission of Chagas' disease.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300007en10.4067/S0716-97602010000300007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	congenital Chagas' disease mechanism of infection tissue invasion
spellingShingle	congenital Chagas' disease mechanism of infection tissue invasion Kemmerling,Ulrike Bosco,Cleo Galanti,Norbel Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
description	Chagas' disease is produced by the haemophlagelated protozoan Trypanosoma cruzi and transmitted by haematophages insects such as Triatoma infestans (vinchuca). Due to vector control, congenital transmission gains importance and is responsible for the presence and expansion of this disease in non-endemic areas. The mechanisms of congenital infection are uncertain. It has been suggested that the parasite reaches the fetus through the bloodstream by crossing the placental barrier, and that congenital Chagas' disease is the result of complex interactions between the immune response, placental factors, and the parasite's characteristics. We review the cellular and molecular mechanisms of infection and invasion of the parasite and how immune and placental factors may modulate this process. Finally, we propose a possible model for the vertical transmission of Chagas' disease.
author	Kemmerling,Ulrike Bosco,Cleo Galanti,Norbel
author_facet	Kemmerling,Ulrike Bosco,Cleo Galanti,Norbel
author_sort	Kemmerling,Ulrike
title	Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
title_short	Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
title_full	Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
title_fullStr	Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
title_full_unstemmed	Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal
title_sort	infection and invasion mechanisms of trypanosoma cruzi in the congenital transmission of chagas' disease: a proposal
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300007
work_keys_str_mv	AT kemmerlingulrike infectionandinvasionmechanismsoftrypanosomacruziinthecongenitaltransmissionofchagasdiseaseaproposal AT boscocleo infectionandinvasionmechanismsoftrypanosomacruziinthecongenitaltransmissionofchagasdiseaseaproposal AT galantinorbel infectionandinvasionmechanismsoftrypanosomacruziinthecongenitaltransmissionofchagasdiseaseaproposal
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Infection and invasion mechanisms of Trypanosoma cruzi in the congenital transmission of Chagas' disease: A proposal

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