Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3

Tumor resistance to traditional cancer treatments poses an important challenge to modern science. Thus, angiogenesis inhibition is an important emerging cancer treatment. Many drugs are tested and corticosteroids have shown interesting results. Herein we investigate the effect on microvessel density...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Garrido,Osvaldo, Letelier,René, Rosas,Carlos, Fuenzalida,Marcela, Ferreira,Arturo, Lemus,David
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2010
Materias:
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300008
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:scielo:S0716-97602010000300008
record_format dspace
spelling oai:scielo:S0716-976020100003000082010-11-30Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3Garrido,OsvaldoLetelier,RenéRosas,CarlosFuenzalida,MarcelaFerreira,ArturoLemus,David angiogenesis betamethasone treatment metastasis Tumor resistance to traditional cancer treatments poses an important challenge to modern science. Thus, angiogenesis inhibition is an important emerging cancer treatment. Many drugs are tested and corticosteroids have shown interesting results. Herein we investigate the effect on microvessel density, survival time and tumoral volume of mice with TA3-MTX-R tumors. Twenty six mice were inoculated with lxlO6 tumor cells, 4-5 days after injection, six mice were injected with PBS (group A) and twenty mice were treated with p-met (group B). All animals from Group A died on day 22. Group B was divided into Bl (treated discontinued) and B2 (treated daily) and observed until day 88. All mice were processed for histo-immunohistochemical analysis and the blood vessels were counted. A decrease in microvessel density and tumoral volume and longer survival times were observed in the treated group. We propose that the antiangiogenic p-met effect explains, at least partially, its tumor inhibitory properties. As an important perspective, we will experimentally combine these strategies with those recently described by us with regard to the important antiangiogenic-antitumor effects of Trypanosoma cruzi calreticulin. Since the molecular targets of these strategies are most likely different, additive or synergic effects are envisaged.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300008en10.4067/S0716-97602010000300008
institution Scielo Chile
collection Scielo Chile
language English
topic angiogenesis
betamethasone treatment
metastasis
spellingShingle angiogenesis
betamethasone treatment
metastasis
Garrido,Osvaldo
Letelier,René
Rosas,Carlos
Fuenzalida,Marcela
Ferreira,Arturo
Lemus,David
Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
description Tumor resistance to traditional cancer treatments poses an important challenge to modern science. Thus, angiogenesis inhibition is an important emerging cancer treatment. Many drugs are tested and corticosteroids have shown interesting results. Herein we investigate the effect on microvessel density, survival time and tumoral volume of mice with TA3-MTX-R tumors. Twenty six mice were inoculated with lxlO6 tumor cells, 4-5 days after injection, six mice were injected with PBS (group A) and twenty mice were treated with p-met (group B). All animals from Group A died on day 22. Group B was divided into Bl (treated discontinued) and B2 (treated daily) and observed until day 88. All mice were processed for histo-immunohistochemical analysis and the blood vessels were counted. A decrease in microvessel density and tumoral volume and longer survival times were observed in the treated group. We propose that the antiangiogenic p-met effect explains, at least partially, its tumor inhibitory properties. As an important perspective, we will experimentally combine these strategies with those recently described by us with regard to the important antiangiogenic-antitumor effects of Trypanosoma cruzi calreticulin. Since the molecular targets of these strategies are most likely different, additive or synergic effects are envisaged.
author Garrido,Osvaldo
Letelier,René
Rosas,Carlos
Fuenzalida,Marcela
Ferreira,Arturo
Lemus,David
author_facet Garrido,Osvaldo
Letelier,René
Rosas,Carlos
Fuenzalida,Marcela
Ferreira,Arturo
Lemus,David
author_sort Garrido,Osvaldo
title Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
title_short Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
title_full Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
title_fullStr Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
title_full_unstemmed Betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma TA3
title_sort betamethasone inhibits tumor development, microvessel density and prolongs survival in mice with a multiresistant adenocarcinoma ta3
publisher Sociedad de Biología de Chile
publishDate 2010
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300008
work_keys_str_mv AT garridoosvaldo betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
AT letelierrene betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
AT rosascarlos betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
AT fuenzalidamarcela betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
AT ferreiraarturo betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
AT lemusdavid betamethasoneinhibitstumordevelopmentmicrovesseldensityandprolongssurvivalinmicewithamultiresistantadenocarcinomata3
_version_ 1718441464142233600