Histocompatibility and Immunogenetics in Cord Blood Transplantation

This review of the immunogenetics of cord blood transplantation attempts to highlight the connections between classical studies and conclusions of the tissue transplantation field as a scholarly endeavor, exemplified by the work of Professor Hoecker, with the motivations and some recent and key resu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rubinstein,Pablo, Hillyer,Christopher
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	Umbilical Cord Blood Hematopoietic Transplantation Histocompatibility Genes HLA matching
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300011
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0716-97602010000300011
record_format	dspace
spelling	oai:scielo:S0716-976020100003000112010-11-30Histocompatibility and Immunogenetics in Cord Blood TransplantationRubinstein,PabloHillyer,Christopher Umbilical Cord Blood Hematopoietic Transplantation Histocompatibility Genes HLA matching This review of the immunogenetics of cord blood transplantation attempts to highlight the connections between classical studies and conclusions of the tissue transplantation field as a scholarly endeavor, exemplified by the work of Professor Hoecker, with the motivations and some recent and key results of clinical cord blood transplantation. The authors review the evolution of understanding of transplantation biology and find that the results of the application of cord blood stem cells to Transplantation Medicine are consistent with the careful experiments of the pioneers in the field, from the results of tumor and normal tissue transplants, histocompatibility immunogenetics, to cell and molecular biology. Recent results of the National Cord Blood Program of the New York Blood Center describe the functioning in cord blood transplantation of factors, well known in transplantation immunogenetics, like the Fl anti-parent effect and the tolerance-like status of donors produced by non-inherited maternal HLA antigens. Consideration of these factors in donor selection strategies can improve the prognosis of transplantation by characterizing "permissibility" in HLA-incompatible transplantation thereby increasing the probability of survival and reducing the likelihood of leukemic relapse.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300011en10.4067/S0716-97602010000300011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Umbilical Cord Blood Hematopoietic Transplantation Histocompatibility Genes HLA matching
spellingShingle	Umbilical Cord Blood Hematopoietic Transplantation Histocompatibility Genes HLA matching Rubinstein,Pablo Hillyer,Christopher Histocompatibility and Immunogenetics in Cord Blood Transplantation
description	This review of the immunogenetics of cord blood transplantation attempts to highlight the connections between classical studies and conclusions of the tissue transplantation field as a scholarly endeavor, exemplified by the work of Professor Hoecker, with the motivations and some recent and key results of clinical cord blood transplantation. The authors review the evolution of understanding of transplantation biology and find that the results of the application of cord blood stem cells to Transplantation Medicine are consistent with the careful experiments of the pioneers in the field, from the results of tumor and normal tissue transplants, histocompatibility immunogenetics, to cell and molecular biology. Recent results of the National Cord Blood Program of the New York Blood Center describe the functioning in cord blood transplantation of factors, well known in transplantation immunogenetics, like the Fl anti-parent effect and the tolerance-like status of donors produced by non-inherited maternal HLA antigens. Consideration of these factors in donor selection strategies can improve the prognosis of transplantation by characterizing "permissibility" in HLA-incompatible transplantation thereby increasing the probability of survival and reducing the likelihood of leukemic relapse.
author	Rubinstein,Pablo Hillyer,Christopher
author_facet	Rubinstein,Pablo Hillyer,Christopher
author_sort	Rubinstein,Pablo
title	Histocompatibility and Immunogenetics in Cord Blood Transplantation
title_short	Histocompatibility and Immunogenetics in Cord Blood Transplantation
title_full	Histocompatibility and Immunogenetics in Cord Blood Transplantation
title_fullStr	Histocompatibility and Immunogenetics in Cord Blood Transplantation
title_full_unstemmed	Histocompatibility and Immunogenetics in Cord Blood Transplantation
title_sort	histocompatibility and immunogenetics in cord blood transplantation
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300011
work_keys_str_mv	AT rubinsteinpablo histocompatibilityandimmunogeneticsincordbloodtransplantation AT hillyerchristopher histocompatibilityandimmunogeneticsincordbloodtransplantation
_version_	1718441465028280320

Histocompatibility and Immunogenetics in Cord Blood Transplantation

Ejemplares similares