Cytoprotective and suicidal signaling in oxidative stress
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated...
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Sociedad de Biología de Chile
2010
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oai:scielo:S0716-976020100003000142010-11-30Cytoprotective and suicidal signaling in oxidative stressVidela,Luis A oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014en10.4067/S0716-97602010000300014 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease |
| spellingShingle |
oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease Videla,Luis A Cytoprotective and suicidal signaling in oxidative stress |
| description |
Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity. |
| author |
Videla,Luis A |
| author_facet |
Videla,Luis A |
| author_sort |
Videla,Luis A |
| title |
Cytoprotective and suicidal signaling in oxidative stress |
| title_short |
Cytoprotective and suicidal signaling in oxidative stress |
| title_full |
Cytoprotective and suicidal signaling in oxidative stress |
| title_fullStr |
Cytoprotective and suicidal signaling in oxidative stress |
| title_full_unstemmed |
Cytoprotective and suicidal signaling in oxidative stress |
| title_sort |
cytoprotective and suicidal signaling in oxidative stress |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014 |
| work_keys_str_mv |
AT videlaluisa cytoprotectiveandsuicidalsignalinginoxidativestress |
| _version_ |
1718441465814712320 |