Cytoprotective and suicidal signaling in oxidative stress

Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated...

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Autor principal:	Videla,Luis A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014
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spelling	oai:scielo:S0716-976020100003000142010-11-30Cytoprotective and suicidal signaling in oxidative stressVidela,Luis A oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014en10.4067/S0716-97602010000300014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease
spellingShingle	oxidative stress thyroid hormone liver preconditioning obesity insulin resistance non-alcoholic fatty liver disease Videla,Luis A Cytoprotective and suicidal signaling in oxidative stress
description	Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state by thyroid hormone administration eliciting the redox upregulation of the expression of proteins affording cell protection as a preconditioning strategy against ischemia-reperfusion liver injury; and (ii) the role of prolonged and severe oxidative stress and insulin resistance as determinant factors in the pathogenesis of non-alcoholic fatty liver disease associated with obesity.
author	Videla,Luis A
author_facet	Videla,Luis A
author_sort	Videla,Luis A
title	Cytoprotective and suicidal signaling in oxidative stress
title_short	Cytoprotective and suicidal signaling in oxidative stress
title_full	Cytoprotective and suicidal signaling in oxidative stress
title_fullStr	Cytoprotective and suicidal signaling in oxidative stress
title_full_unstemmed	Cytoprotective and suicidal signaling in oxidative stress
title_sort	cytoprotective and suicidal signaling in oxidative stress
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300014
work_keys_str_mv	AT videlaluisa cytoprotectiveandsuicidalsignalinginoxidativestress
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Cytoprotective and suicidal signaling in oxidative stress

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