Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents

Parkia platycephala Benth. (Leguminosae - Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gast...

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Autores principales:	Fernandes,Hélio B, Silva,Francilene V, Passos,Flávia Franceli B, Bezerra,Roosevelt D S, Chaves,Mariana H, Oliveira,Francisco A, Meneses Oliveira,Rita C
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2010
Materias:	antioxidant ethanol gastroprotection nitric oxide Parkia platycephala ulcer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400010
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spelling	oai:scielo:S0716-976020100004000102011-02-01Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodentsFernandes,Hélio BSilva,Francilene VPassos,Flávia Franceli BBezerra,Roosevelt D SChaves,Mariana HOliveira,Francisco AMeneses Oliveira,Rita C antioxidant ethanol gastroprotection nitric oxide Parkia platycephala ulcer Parkia platycephala Benth. (Leguminosae - Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemia-reperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52 %, respectively), but it was not able to protect gastric mucosa against indomethacin-induced lesions. Results show a possible participation of the NO-synthase pathway in the gastroprotection and an antioxidant activity, by the increase of the catalase activity. The participation of prostaglandins and potassium channels sensitive to ATP in the gastroprotective effect of Pp-EtOH seems less likely to occur. More comprehensive studies, therefore, should be carried out to elucidate the antiulcerative effects of this promising natural product against this gastrointestinal disorder.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.43 n.4 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400010en10.4067/S0716-97602010000400010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidant ethanol gastroprotection nitric oxide Parkia platycephala ulcer
spellingShingle	antioxidant ethanol gastroprotection nitric oxide Parkia platycephala ulcer Fernandes,Hélio B Silva,Francilene V Passos,Flávia Franceli B Bezerra,Roosevelt D S Chaves,Mariana H Oliveira,Francisco A Meneses Oliveira,Rita C Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
description	Parkia platycephala Benth. (Leguminosae - Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemia-reperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52 %, respectively), but it was not able to protect gastric mucosa against indomethacin-induced lesions. Results show a possible participation of the NO-synthase pathway in the gastroprotection and an antioxidant activity, by the increase of the catalase activity. The participation of prostaglandins and potassium channels sensitive to ATP in the gastroprotective effect of Pp-EtOH seems less likely to occur. More comprehensive studies, therefore, should be carried out to elucidate the antiulcerative effects of this promising natural product against this gastrointestinal disorder.
author	Fernandes,Hélio B Silva,Francilene V Passos,Flávia Franceli B Bezerra,Roosevelt D S Chaves,Mariana H Oliveira,Francisco A Meneses Oliveira,Rita C
author_facet	Fernandes,Hélio B Silva,Francilene V Passos,Flávia Franceli B Bezerra,Roosevelt D S Chaves,Mariana H Oliveira,Francisco A Meneses Oliveira,Rita C
author_sort	Fernandes,Hélio B
title	Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
title_short	Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
title_full	Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
title_fullStr	Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
title_full_unstemmed	Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents
title_sort	gastroprotective effect of the ethanolic extract of parkia platycephala benth. leaves against acute gastric lesion models in rodents
publisher	Sociedad de Biología de Chile
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400010
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Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents

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