Location matters: the endoplasmic reticulum and protein trafficking in dendrites

Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current u...

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Autores principales:	Ramírez,Omar A, Härtel,Steffen, Couve,Andrés
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	endoplasmic reticulum protein trafficking dendrites neuron
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003
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spelling	oai:scielo:S0716-976020110001000032011-09-01Location matters: the endoplasmic reticulum and protein trafficking in dendritesRamírez,Omar AHärtel,SteffenCouve,Andrés endoplasmic reticulum protein trafficking dendrites neuron Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003en10.4067/S0716-97602011000100003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	endoplasmic reticulum protein trafficking dendrites neuron
spellingShingle	endoplasmic reticulum protein trafficking dendrites neuron Ramírez,Omar A Härtel,Steffen Couve,Andrés Location matters: the endoplasmic reticulum and protein trafficking in dendrites
description	Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
author	Ramírez,Omar A Härtel,Steffen Couve,Andrés
author_facet	Ramírez,Omar A Härtel,Steffen Couve,Andrés
author_sort	Ramírez,Omar A
title	Location matters: the endoplasmic reticulum and protein trafficking in dendrites
title_short	Location matters: the endoplasmic reticulum and protein trafficking in dendrites
title_full	Location matters: the endoplasmic reticulum and protein trafficking in dendrites
title_fullStr	Location matters: the endoplasmic reticulum and protein trafficking in dendrites
title_full_unstemmed	Location matters: the endoplasmic reticulum and protein trafficking in dendrites
title_sort	location matters: the endoplasmic reticulum and protein trafficking in dendrites
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003
work_keys_str_mv	AT ramirezomara locationmatterstheendoplasmicreticulumandproteintraffickingindendrites AT hartelsteffen locationmatterstheendoplasmicreticulumandproteintraffickingindendrites AT couveandres locationmatterstheendoplasmicreticulumandproteintraffickingindendrites
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Location matters: the endoplasmic reticulum and protein trafficking in dendrites

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