The balance between GMD and OFUT1 regulates Notch signaling pathway activity by modulating Notch stability

The balance between GMD and OFUT1 regulates Notch signaling pathway activity by modulating Notch stability

The Notch signaling pathway plays an important role in development and physiology. In Drosophila, Notch is activated by its Delta or Serrate ligands, depending in part on the sugar modifications present in its extracellular domain. O-fucosyltransferase-1 (OFUT1) performs the first glycosylation step...

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Autores principales: Glavic,Alvaro, López-Varea,Ana, de Celis,José F
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2011
Materias:
Notch
GMD
O-fucosyltranserase
Drosophila
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100004
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