Regulation of cell polarity by controlled proteolytic systems
Epithelial and neuronal cells are highly asymmetric, with discrete regions responsible for different roles that underlie the generation of specific compartments within cells that are distinct in biochemical composition, structure, and morphology that ultimately lead to distinct functions. Controlled...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2011
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oai:scielo:S0716-976020110001000052011-09-01Regulation of cell polarity by controlled proteolytic systemsBórquez,Daniel AGonzález-Billault,Christian calpain neuronal polarity proteolytic systems ubiquitin proteasome Epithelial and neuronal cells are highly asymmetric, with discrete regions responsible for different roles that underlie the generation of specific compartments within cells that are distinct in biochemical composition, structure, and morphology that ultimately lead to distinct functions. Controlled and specific molecular targeting and sorting have been studied to understand the generation of asymmetric domains inside cells. Recently, a new and complementary explanation has emerged to account for the generation of domains that are enriched by a subset of proteins or polarization determinants: local proteolysis. In this review, we discuss the most conspicuous proteolytic systems that may contribute to the generation of cell polarity, namely the ubiquitin-proteosome and the calpain systems. Specifically, we focus this review on two cellular processes that depend on the acquisition of cell polarity; cell migration and the establishment of an axon in a neuronal cell.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100005en10.4067/S0716-97602011000100005 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
calpain neuronal polarity proteolytic systems ubiquitin proteasome |
| spellingShingle |
calpain neuronal polarity proteolytic systems ubiquitin proteasome Bórquez,Daniel A González-Billault,Christian Regulation of cell polarity by controlled proteolytic systems |
| description |
Epithelial and neuronal cells are highly asymmetric, with discrete regions responsible for different roles that underlie the generation of specific compartments within cells that are distinct in biochemical composition, structure, and morphology that ultimately lead to distinct functions. Controlled and specific molecular targeting and sorting have been studied to understand the generation of asymmetric domains inside cells. Recently, a new and complementary explanation has emerged to account for the generation of domains that are enriched by a subset of proteins or polarization determinants: local proteolysis. In this review, we discuss the most conspicuous proteolytic systems that may contribute to the generation of cell polarity, namely the ubiquitin-proteosome and the calpain systems. Specifically, we focus this review on two cellular processes that depend on the acquisition of cell polarity; cell migration and the establishment of an axon in a neuronal cell. |
| author |
Bórquez,Daniel A González-Billault,Christian |
| author_facet |
Bórquez,Daniel A González-Billault,Christian |
| author_sort |
Bórquez,Daniel A |
| title |
Regulation of cell polarity by controlled proteolytic systems |
| title_short |
Regulation of cell polarity by controlled proteolytic systems |
| title_full |
Regulation of cell polarity by controlled proteolytic systems |
| title_fullStr |
Regulation of cell polarity by controlled proteolytic systems |
| title_full_unstemmed |
Regulation of cell polarity by controlled proteolytic systems |
| title_sort |
regulation of cell polarity by controlled proteolytic systems |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100005 |
| work_keys_str_mv |
AT borquezdaniela regulationofcellpolaritybycontrolledproteolyticsystems AT gonzalezbillaultchristian regulationofcellpolaritybycontrolledproteolyticsystems |
| _version_ |
1718441470682202112 |