Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity

Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host ti...

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Autores principales:	Llanos,Carolina, Carreño,Leandro J, Kalergis,Alexis M
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	dendritic cells T cells immunological synapse autoimmunity tolerance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007
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spelling	oai:scielo:S0716-976020110001000072011-09-01Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunityLlanos,CarolinaCarreño,Leandro JKalergis,Alexis M dendritic cells T cells immunological synapse autoimmunity tolerance Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell function. Therefore, because DCs work as central modulators of immune tolerance, it is likely that alterations in their function can lead to the onset of autoimmune-inflammatory diseases. By modulating DC function, novel pathways in antigen-specific tolerance could be established. In this article, the possible contribution of altered DC-T cell interactions to the onset of autoimmunity are discussed. In addition, we expand on the notion that some of the functions of these cells could be relevant targets for intervening therapies aimed to restore the balance or even prevent the loss of tolerance.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007en10.4067/S0716-97602011000100007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	dendritic cells T cells immunological synapse autoimmunity tolerance
spellingShingle	dendritic cells T cells immunological synapse autoimmunity tolerance Llanos,Carolina Carreño,Leandro J Kalergis,Alexis M Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
description	Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell function. Therefore, because DCs work as central modulators of immune tolerance, it is likely that alterations in their function can lead to the onset of autoimmune-inflammatory diseases. By modulating DC function, novel pathways in antigen-specific tolerance could be established. In this article, the possible contribution of altered DC-T cell interactions to the onset of autoimmunity are discussed. In addition, we expand on the notion that some of the functions of these cells could be relevant targets for intervening therapies aimed to restore the balance or even prevent the loss of tolerance.
author	Llanos,Carolina Carreño,Leandro J Kalergis,Alexis M
author_facet	Llanos,Carolina Carreño,Leandro J Kalergis,Alexis M
author_sort	Llanos,Carolina
title	Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
title_short	Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
title_full	Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
title_fullStr	Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
title_full_unstemmed	Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
title_sort	contribution of dendritic cell/t cell interactions to triggering and maintaining autoimmunity
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007
work_keys_str_mv	AT llanoscarolina contributionofdendriticcelltcellinteractionstotriggeringandmaintainingautoimmunity AT carrenoleandroj contributionofdendriticcelltcellinteractionstotriggeringandmaintainingautoimmunity AT kalergisalexism contributionofdendriticcelltcellinteractionstotriggeringandmaintainingautoimmunity
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Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity

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