Modulation of spermatozoon acrosome reaction

Spermatozoon acrosome reaction is an exocytotic event of the utmost importance for the development of mammalian fertilisation. Current evidence shows that the triggering of the acrosome reaction (AR) could be regulated by the action of diverse compounds, namely, metabolites, neurotransmitters and ho...

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Autores principales:	Vigil,Pilar, Orellana,Renán F, Cortés,Manuel E
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	capacitation gamma-aminobutyric acid hormone modulation steroids spermatozoon acrosome reaction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200007
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spelling	oai:scielo:S0716-976020110002000072011-09-20Modulation of spermatozoon acrosome reactionVigil,PilarOrellana,Renán FCortés,Manuel E capacitation gamma-aminobutyric acid hormone modulation steroids spermatozoon acrosome reaction Spermatozoon acrosome reaction is an exocytotic event of the utmost importance for the development of mammalian fertilisation. Current evidence shows that the triggering of the acrosome reaction (AR) could be regulated by the action of diverse compounds, namely, metabolites, neurotransmitters and hormones. The aim of the present review is to describe the modulating effects of several compounds that have been classified as inductors or inhibitors of acrosome reaction. Among AR inductors, it is necessary to mention progesterone, angiotensin II, atrial natriuretic peptide, cathecolamines, insulin, leptin, relaxin and other hormones. Regarding the inhibitors, oestradiol and epidermal growth factor are among the substances that retard AR. It is worth mentioning that gamma-aminobutyric acid, a neurotransmitter known to be an inhibitor in the central nervous system, has been shown to induce AR. The multiple hormones located in the fluids of the female reproductive tract are also likely to act as subtle regulators of AR, constituting a fundamental aspect for the development of successful fertilisation. Finally, it is necessary to emphasise that the study of regulation exerted by hormones and other compounds on AR is essential for further understanding of mammalian reproductive biology, especially spermatozoon physiology.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.2 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200007en10.4067/S0716-97602011000200007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	capacitation gamma-aminobutyric acid hormone modulation steroids spermatozoon acrosome reaction
spellingShingle	capacitation gamma-aminobutyric acid hormone modulation steroids spermatozoon acrosome reaction Vigil,Pilar Orellana,Renán F Cortés,Manuel E Modulation of spermatozoon acrosome reaction
description	Spermatozoon acrosome reaction is an exocytotic event of the utmost importance for the development of mammalian fertilisation. Current evidence shows that the triggering of the acrosome reaction (AR) could be regulated by the action of diverse compounds, namely, metabolites, neurotransmitters and hormones. The aim of the present review is to describe the modulating effects of several compounds that have been classified as inductors or inhibitors of acrosome reaction. Among AR inductors, it is necessary to mention progesterone, angiotensin II, atrial natriuretic peptide, cathecolamines, insulin, leptin, relaxin and other hormones. Regarding the inhibitors, oestradiol and epidermal growth factor are among the substances that retard AR. It is worth mentioning that gamma-aminobutyric acid, a neurotransmitter known to be an inhibitor in the central nervous system, has been shown to induce AR. The multiple hormones located in the fluids of the female reproductive tract are also likely to act as subtle regulators of AR, constituting a fundamental aspect for the development of successful fertilisation. Finally, it is necessary to emphasise that the study of regulation exerted by hormones and other compounds on AR is essential for further understanding of mammalian reproductive biology, especially spermatozoon physiology.
author	Vigil,Pilar Orellana,Renán F Cortés,Manuel E
author_facet	Vigil,Pilar Orellana,Renán F Cortés,Manuel E
author_sort	Vigil,Pilar
title	Modulation of spermatozoon acrosome reaction
title_short	Modulation of spermatozoon acrosome reaction
title_full	Modulation of spermatozoon acrosome reaction
title_fullStr	Modulation of spermatozoon acrosome reaction
title_full_unstemmed	Modulation of spermatozoon acrosome reaction
title_sort	modulation of spermatozoon acrosome reaction
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200007
work_keys_str_mv	AT vigilpilar modulationofspermatozoonacrosomereaction AT orellanarenanf modulationofspermatozoonacrosomereaction AT cortesmanuele modulationofspermatozoonacrosomereaction
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Modulation of spermatozoon acrosome reaction

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