Vitamin C and oxidative stress in the seminiferous epithelium

In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In...

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Autores principales:	Angulo,Constanza, Maldonado,Rodrigo, Pulgar,Eduardo, Mancilla,Héctor, Córdova,Alex, Villarroel,Franz, Castro,Maite A, Concha,Ilona I
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	ascorbic acid oxidative stress GLUT Sertoli cells SVCT vitamin C transporters
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200009
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spelling	oai:scielo:S0716-976020110002000092011-09-20Vitamin C and oxidative stress in the seminiferous epitheliumAngulo,ConstanzaMaldonado,RodrigoPulgar,EduardoMancilla,HéctorCórdova,AlexVillarroel,FranzCastro,Maite AConcha,Ilona I ascorbic acid oxidative stress GLUT Sertoli cells SVCT vitamin C transporters In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, antioxidant defence plays a critical role in male fertility. Vitamin C, a micronutrient required for a wide variety of metabolic functions, has long been associated with male reproduction. Two systems for vitamin C transport have been described in mammals. Facilitative hexose transporters (GLUTs), with 14 known isoforms to date, GLUT1-GLUT14, transport the oxidized form of vitamin C (dehydroascorbic acid) into the cells. Sodium ascorbic acid co-transporters (SVCTs), SVCT1 and SVCT2 transport the reduced form of vitamin C (ascorbic acid). Sertoli cells control germ cell proliferation and differentiation through cell-cell communication and form the blood-testis barrier. Because the blood-testis barrier limits direct access of molecules from the plasma into the adluminal compartment of the seminiferous tubule, one important question is the method by which germ cells obtain vitamin C. Some interesting results have thrown light on this matter. Expression of SVCT2 and some isoforms of GLUT transporters in the testis have previously been described. Our group has demonstrated that Sertoli cells express functionally active vitamin C transporters. Kinetic characteristics were described for both transport systems (SVCT and GLUT systems). Sertoli cells are able to transport both forms of vitamin C. These findings are extremely relevant, because Sertoli cells may control the amount of vitamin C in the adluminal compartment, as well as regulating the availability of this metabolite throughout spermatogenesis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.2 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200009en10.4067/S0716-97602011000200009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	ascorbic acid oxidative stress GLUT Sertoli cells SVCT vitamin C transporters
spellingShingle	ascorbic acid oxidative stress GLUT Sertoli cells SVCT vitamin C transporters Angulo,Constanza Maldonado,Rodrigo Pulgar,Eduardo Mancilla,Héctor Córdova,Alex Villarroel,Franz Castro,Maite A Concha,Ilona I Vitamin C and oxidative stress in the seminiferous epithelium
description	In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, antioxidant defence plays a critical role in male fertility. Vitamin C, a micronutrient required for a wide variety of metabolic functions, has long been associated with male reproduction. Two systems for vitamin C transport have been described in mammals. Facilitative hexose transporters (GLUTs), with 14 known isoforms to date, GLUT1-GLUT14, transport the oxidized form of vitamin C (dehydroascorbic acid) into the cells. Sodium ascorbic acid co-transporters (SVCTs), SVCT1 and SVCT2 transport the reduced form of vitamin C (ascorbic acid). Sertoli cells control germ cell proliferation and differentiation through cell-cell communication and form the blood-testis barrier. Because the blood-testis barrier limits direct access of molecules from the plasma into the adluminal compartment of the seminiferous tubule, one important question is the method by which germ cells obtain vitamin C. Some interesting results have thrown light on this matter. Expression of SVCT2 and some isoforms of GLUT transporters in the testis have previously been described. Our group has demonstrated that Sertoli cells express functionally active vitamin C transporters. Kinetic characteristics were described for both transport systems (SVCT and GLUT systems). Sertoli cells are able to transport both forms of vitamin C. These findings are extremely relevant, because Sertoli cells may control the amount of vitamin C in the adluminal compartment, as well as regulating the availability of this metabolite throughout spermatogenesis.
author	Angulo,Constanza Maldonado,Rodrigo Pulgar,Eduardo Mancilla,Héctor Córdova,Alex Villarroel,Franz Castro,Maite A Concha,Ilona I
author_facet	Angulo,Constanza Maldonado,Rodrigo Pulgar,Eduardo Mancilla,Héctor Córdova,Alex Villarroel,Franz Castro,Maite A Concha,Ilona I
author_sort	Angulo,Constanza
title	Vitamin C and oxidative stress in the seminiferous epithelium
title_short	Vitamin C and oxidative stress in the seminiferous epithelium
title_full	Vitamin C and oxidative stress in the seminiferous epithelium
title_fullStr	Vitamin C and oxidative stress in the seminiferous epithelium
title_full_unstemmed	Vitamin C and oxidative stress in the seminiferous epithelium
title_sort	vitamin c and oxidative stress in the seminiferous epithelium
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200009
work_keys_str_mv	AT anguloconstanza vitamincandoxidativestressintheseminiferousepithelium AT maldonadorodrigo vitamincandoxidativestressintheseminiferousepithelium AT pulgareduardo vitamincandoxidativestressintheseminiferousepithelium AT mancillahector vitamincandoxidativestressintheseminiferousepithelium AT cordovaalex vitamincandoxidativestressintheseminiferousepithelium AT villarroelfranz vitamincandoxidativestressintheseminiferousepithelium AT castromaitea vitamincandoxidativestressintheseminiferousepithelium AT conchailonai vitamincandoxidativestressintheseminiferousepithelium
_version_	1718441475425959936

Vitamin C and oxidative stress in the seminiferous epithelium

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