The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells

Numerous studies have repeatedly shown that women who smoke experience problems establishing and maintaining pregnancies, and recent work has further demonstrated that the in utero effects of smoke may not be manifested until months or even years after birth. The purpose of this review is to examine...

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Autores principales:	Talbot,Prue, Lin,Sabrina
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	cigarette smoke embryos fertilization IVF stem cells toxicology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200011
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spelling	oai:scielo:S0716-976020110002000112011-09-20The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cellsTalbot,PrueLin,Sabrina cigarette smoke embryos fertilization IVF stem cells toxicology Numerous studies have repeatedly shown that women who smoke experience problems establishing and maintaining pregnancies, and recent work has further demonstrated that the in utero effects of smoke may not be manifested until months or even years after birth. The purpose of this review is to examine the recent literature dealing with the effects of cigarette smoke on the earliest stages of human prenatal development. Studies in this area have included the use of animal models, patients undergoing in vitro fertilization, and embryonic stem cell models. Events leading to fertilization, such as cumulus expansion, hyperactivation of sperm motility, and oocyte pick-up by the oviduct are all impaired by smoke exposure in animal models. Steps crucial to fertilization such as the acrosome reaction and sperm binding to the zona pellucida are likewise inhibited by cigarette smoke. Preimplantation embryos and stem cells that model embryos show a number of adverse responses to smoke exposure, including poor adhesion to extracellular matrices, diminished survival and proliferation, and increased apoptosis. The current literature demonstrates that the earliest stages of prenatal development are sensitive to smoke exposure and indicates that pregnant women should be advised not to smoke during this time.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.2 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200011en10.4067/S0716-97602011000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	cigarette smoke embryos fertilization IVF stem cells toxicology
spellingShingle	cigarette smoke embryos fertilization IVF stem cells toxicology Talbot,Prue Lin,Sabrina The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
description	Numerous studies have repeatedly shown that women who smoke experience problems establishing and maintaining pregnancies, and recent work has further demonstrated that the in utero effects of smoke may not be manifested until months or even years after birth. The purpose of this review is to examine the recent literature dealing with the effects of cigarette smoke on the earliest stages of human prenatal development. Studies in this area have included the use of animal models, patients undergoing in vitro fertilization, and embryonic stem cell models. Events leading to fertilization, such as cumulus expansion, hyperactivation of sperm motility, and oocyte pick-up by the oviduct are all impaired by smoke exposure in animal models. Steps crucial to fertilization such as the acrosome reaction and sperm binding to the zona pellucida are likewise inhibited by cigarette smoke. Preimplantation embryos and stem cells that model embryos show a number of adverse responses to smoke exposure, including poor adhesion to extracellular matrices, diminished survival and proliferation, and increased apoptosis. The current literature demonstrates that the earliest stages of prenatal development are sensitive to smoke exposure and indicates that pregnant women should be advised not to smoke during this time.
author	Talbot,Prue Lin,Sabrina
author_facet	Talbot,Prue Lin,Sabrina
author_sort	Talbot,Prue
title	The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
title_short	The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
title_full	The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
title_fullStr	The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
title_full_unstemmed	The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
title_sort	effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200011
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The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells

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