Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution

We found a consistent 3-site periodicity of the X²9 values for the heterogeneity of the distribution of the second base in relation to the first base of dinucleotides separated by 0 (contiguous), 1, 2, 3 ... 17 (K) nucleotide sites in Drosophila mtDNA. Triplets of X²9 values were found where the fir...

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Autor principal:	Valenzuela,Carlos Y
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	DNA organization non-protein-coding evolution ordered nucleotide sequences inter-base associations refutation of neutralism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300010
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spelling	oai:scielo:S0716-976020110003000102011-11-07Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolutionValenzuela,Carlos Y DNA organization non-protein-coding evolution ordered nucleotide sequences inter-base associations refutation of neutralism We found a consistent 3-site periodicity of the X²9 values for the heterogeneity of the distribution of the second base in relation to the first base of dinucleotides separated by 0 (contiguous), 1, 2, 3 ... 17 (K) nucleotide sites in Drosophila mtDNA. Triplets of X²9 values were found where the first was over 300 and the second and third ranged between 37 and 114 (previous studies). In this study, the periodicity was significant until separation of 2011K, and a structure of deviations from randomness among dinucleotides was found. The most deviant dinucleotides were G-G, G-C and C-G for the first, second and third element of the triplet, respectively. In these three cases there were more dinucleotides observed than expected. This inter-bases correlation and periodicity may be related to the tertiary structure of circular DNA, like that of prokaryotes and mitochondria, to protect and preserve it. The mtDNA with 19.517 bp was divided into four equal segments of 4.879 bp. The fourth sub-segment presented a very low proportion of G and C, the internucleotide interaction was weaker in this sub-segment and no periodicity was found. The maintenance of this mtDNA structure and organization for millions of generations, in spite of a high recurrent mutation rate, does not support the notion of neutralism or near neutralism. The high level of internucleotide interaction and periodicity indicate that every nucleotide is co-adapted with the residual genome.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.3 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300010en10.4067/S0716-97602011000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	DNA organization non-protein-coding evolution ordered nucleotide sequences inter-base associations refutation of neutralism
spellingShingle	DNA organization non-protein-coding evolution ordered nucleotide sequences inter-base associations refutation of neutralism Valenzuela,Carlos Y Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
description	We found a consistent 3-site periodicity of the X²9 values for the heterogeneity of the distribution of the second base in relation to the first base of dinucleotides separated by 0 (contiguous), 1, 2, 3 ... 17 (K) nucleotide sites in Drosophila mtDNA. Triplets of X²9 values were found where the first was over 300 and the second and third ranged between 37 and 114 (previous studies). In this study, the periodicity was significant until separation of 2011K, and a structure of deviations from randomness among dinucleotides was found. The most deviant dinucleotides were G-G, G-C and C-G for the first, second and third element of the triplet, respectively. In these three cases there were more dinucleotides observed than expected. This inter-bases correlation and periodicity may be related to the tertiary structure of circular DNA, like that of prokaryotes and mitochondria, to protect and preserve it. The mtDNA with 19.517 bp was divided into four equal segments of 4.879 bp. The fourth sub-segment presented a very low proportion of G and C, the internucleotide interaction was weaker in this sub-segment and no periodicity was found. The maintenance of this mtDNA structure and organization for millions of generations, in spite of a high recurrent mutation rate, does not support the notion of neutralism or near neutralism. The high level of internucleotide interaction and periodicity indicate that every nucleotide is co-adapted with the residual genome.
author	Valenzuela,Carlos Y
author_facet	Valenzuela,Carlos Y
author_sort	Valenzuela,Carlos Y
title	Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
title_short	Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
title_full	Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
title_fullStr	Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
title_full_unstemmed	Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution
title_sort	heterogeneous periodicity of drosophila mtdna: new refutations of neutral and nearly neutral evolution
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300010
work_keys_str_mv	AT valenzuelacarlosy heterogeneousperiodicityofdrosophilamtdnanewrefutationsofneutralandnearlyneutralevolution
_version_	1718441478799228928

Heterogeneous periodicity of drosophila mtDNA: new refutations of neutral and nearly neutral evolution

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