Trait anxiety affects the orofacial nociceptive response in rats

The aims of the present study were to assess the influence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Forty-four rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profiles. In accordance to the parameter "Percen...

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Autores principales:	Matos,Anne Caroline C, Teixeira-Silva,Flavia, Goes,Tiago C, Quintans Júnior,Lucindo J, Albuquerque Júnior,Ricardo Luiz C, Bonjardim,Leonardo R
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	trait anxiety formalin test orofacial nociception state anxiety
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400007
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spelling	oai:scielo:S0716-976020110004000072012-02-10Trait anxiety affects the orofacial nociceptive response in ratsMatos,Anne Caroline CTeixeira-Silva,FlaviaGoes,Tiago CQuintans Júnior,Lucindo JAlbuquerque Júnior,Ricardo Luiz CBonjardim,Leonardo R trait anxiety formalin test orofacial nociception state anxiety The aims of the present study were to assess the influence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Forty-four rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profiles. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait anxiety when presenting values below the 1st quartile, or above the 3rd quartile, respectively. A week later, formalin-1.5% was injected into the upper lip of each animal. The behavioural nociceptive response, characterized by increased orofacial rubbing (OR), was quantified for 30 minutes, as follows: Total time OR (0-30 minutes: total pain), 1st phase OR (0-6 minutes: neurogenic pain), and 2nd phase OR (12-30 minutes: inflammatory pain). Immediately after this test, but still under the effect of formalin, the rats were submitted to the Elevated Plus-maze test (EPM). The results showed that the high trait anxiety individuals presented higher frequency of OR than the low trait anxiety ones, except during the neurogenic pain period. However, no correlation was found between OR frequency and levels of state anxiety presented on the EPM. In conclusion, the animals presenting higher anxiety profiles were the most susceptible to orofacial pain, nevertheless, orofacial pain did not influence state anxiety.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.4 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400007en10.4067/S0716-97602011000400007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	trait anxiety formalin test orofacial nociception state anxiety
spellingShingle	trait anxiety formalin test orofacial nociception state anxiety Matos,Anne Caroline C Teixeira-Silva,Flavia Goes,Tiago C Quintans Júnior,Lucindo J Albuquerque Júnior,Ricardo Luiz C Bonjardim,Leonardo R Trait anxiety affects the orofacial nociceptive response in rats
description	The aims of the present study were to assess the influence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Forty-four rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profiles. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait anxiety when presenting values below the 1st quartile, or above the 3rd quartile, respectively. A week later, formalin-1.5% was injected into the upper lip of each animal. The behavioural nociceptive response, characterized by increased orofacial rubbing (OR), was quantified for 30 minutes, as follows: Total time OR (0-30 minutes: total pain), 1st phase OR (0-6 minutes: neurogenic pain), and 2nd phase OR (12-30 minutes: inflammatory pain). Immediately after this test, but still under the effect of formalin, the rats were submitted to the Elevated Plus-maze test (EPM). The results showed that the high trait anxiety individuals presented higher frequency of OR than the low trait anxiety ones, except during the neurogenic pain period. However, no correlation was found between OR frequency and levels of state anxiety presented on the EPM. In conclusion, the animals presenting higher anxiety profiles were the most susceptible to orofacial pain, nevertheless, orofacial pain did not influence state anxiety.
author	Matos,Anne Caroline C Teixeira-Silva,Flavia Goes,Tiago C Quintans Júnior,Lucindo J Albuquerque Júnior,Ricardo Luiz C Bonjardim,Leonardo R
author_facet	Matos,Anne Caroline C Teixeira-Silva,Flavia Goes,Tiago C Quintans Júnior,Lucindo J Albuquerque Júnior,Ricardo Luiz C Bonjardim,Leonardo R
author_sort	Matos,Anne Caroline C
title	Trait anxiety affects the orofacial nociceptive response in rats
title_short	Trait anxiety affects the orofacial nociceptive response in rats
title_full	Trait anxiety affects the orofacial nociceptive response in rats
title_fullStr	Trait anxiety affects the orofacial nociceptive response in rats
title_full_unstemmed	Trait anxiety affects the orofacial nociceptive response in rats
title_sort	trait anxiety affects the orofacial nociceptive response in rats
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400007
work_keys_str_mv	AT matosannecarolinec traitanxietyaffectstheorofacialnociceptiveresponseinrats AT teixeirasilvaflavia traitanxietyaffectstheorofacialnociceptiveresponseinrats AT goestiagoc traitanxietyaffectstheorofacialnociceptiveresponseinrats AT quintansjuniorlucindoj traitanxietyaffectstheorofacialnociceptiveresponseinrats AT albuquerquejuniorricardoluizc traitanxietyaffectstheorofacialnociceptiveresponseinrats AT bonjardimleonardor traitanxietyaffectstheorofacialnociceptiveresponseinrats
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Trait anxiety affects the orofacial nociceptive response in rats

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