Anti-inflammatory and redox-protective activities of citronellal
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally,...
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Sociedad de Biología de Chile
2011
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oai:scielo:S0716-976020110004000082012-02-10Anti-inflammatory and redox-protective activities of citronellalMelo,Mônica SGuimarães,Adriana GSantana,Michele FSiqueira,Rosana SDe Lima,Amanda Do Carmo BDias,Antonio SSantos,Márcio Roberto VOnofre,Alexandre S.C.Quintans,Jullyana S.S.De Sousa,Damião PAlmeida,Jackson R.G.S.Estevam,Charles SAraujo,Brancilene SQuintans-Júnior,Lucindo J Monoterpene citronellal anti-inflammatory redox The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefit to manage inflammatory disorders and correlated damages caused by oxidant agents.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.4 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008en10.4067/S0716-97602011000400008 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Monoterpene citronellal anti-inflammatory redox |
| spellingShingle |
Monoterpene citronellal anti-inflammatory redox Melo,Mônica S Guimarães,Adriana G Santana,Michele F Siqueira,Rosana S De Lima,Amanda Do Carmo B Dias,Antonio S Santos,Márcio Roberto V Onofre,Alexandre S.C. Quintans,Jullyana S.S. De Sousa,Damião P Almeida,Jackson R.G.S. Estevam,Charles S Araujo,Brancilene S Quintans-Júnior,Lucindo J Anti-inflammatory and redox-protective activities of citronellal |
| description |
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefit to manage inflammatory disorders and correlated damages caused by oxidant agents. |
| author |
Melo,Mônica S Guimarães,Adriana G Santana,Michele F Siqueira,Rosana S De Lima,Amanda Do Carmo B Dias,Antonio S Santos,Márcio Roberto V Onofre,Alexandre S.C. Quintans,Jullyana S.S. De Sousa,Damião P Almeida,Jackson R.G.S. Estevam,Charles S Araujo,Brancilene S Quintans-Júnior,Lucindo J |
| author_facet |
Melo,Mônica S Guimarães,Adriana G Santana,Michele F Siqueira,Rosana S De Lima,Amanda Do Carmo B Dias,Antonio S Santos,Márcio Roberto V Onofre,Alexandre S.C. Quintans,Jullyana S.S. De Sousa,Damião P Almeida,Jackson R.G.S. Estevam,Charles S Araujo,Brancilene S Quintans-Júnior,Lucindo J |
| author_sort |
Melo,Mônica S |
| title |
Anti-inflammatory and redox-protective activities of citronellal |
| title_short |
Anti-inflammatory and redox-protective activities of citronellal |
| title_full |
Anti-inflammatory and redox-protective activities of citronellal |
| title_fullStr |
Anti-inflammatory and redox-protective activities of citronellal |
| title_full_unstemmed |
Anti-inflammatory and redox-protective activities of citronellal |
| title_sort |
anti-inflammatory and redox-protective activities of citronellal |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008 |
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