Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl

In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on h...

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Autores principales:	Sun,Jia-Long, Zou,Xiao, Liu,Ai-Ying, Xiao,Tang-Fu
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2011
Materias:	Monascus spp. monacolin K fungal elicitor mutagenesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400010
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spelling	oai:scielo:S0716-976020110004000102012-02-10Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiClSun,Jia-LongZou,XiaoLiu,Ai-YingXiao,Tang-Fu Monascus spp. monacolin K fungal elicitor mutagenesis In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on how to increase the production of monacolin K by Monascus purpureus. In the present study, we investigated the effect of the fungal elicitor and the mutagenesis of UV & LiCl on the amount of monacolin K produced by Monascus purpureus. The fugal elicitor, Sporobolomyces huaxiensis, was isolated from tea leaves and its filtrate was added into the culture filtrate of Monascus purpureus during growth to induct the production of monacolin K. The results showed that the highest amount of monacolin K produced by the liquid fermentation was 446.92 mg/mL, which was produced after the fungal elicitor was added to the culture filtrate of Monascus purpureus on the day 4; this amount was approximately 6 times greater than that of the control culture filtrate, whereas the highest amount of monacolin K produced by the mutated strain was 3 times greater than the control culture after the irradiation of UV light in the presence of 1.0 % LiCl in the medium.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.44 n.4 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400010en10.4067/S0716-97602011000400010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Monascus spp. monacolin K fungal elicitor mutagenesis
spellingShingle	Monascus spp. monacolin K fungal elicitor mutagenesis Sun,Jia-Long Zou,Xiao Liu,Ai-Ying Xiao,Tang-Fu Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
description	In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on how to increase the production of monacolin K by Monascus purpureus. In the present study, we investigated the effect of the fungal elicitor and the mutagenesis of UV & LiCl on the amount of monacolin K produced by Monascus purpureus. The fugal elicitor, Sporobolomyces huaxiensis, was isolated from tea leaves and its filtrate was added into the culture filtrate of Monascus purpureus during growth to induct the production of monacolin K. The results showed that the highest amount of monacolin K produced by the liquid fermentation was 446.92 mg/mL, which was produced after the fungal elicitor was added to the culture filtrate of Monascus purpureus on the day 4; this amount was approximately 6 times greater than that of the control culture filtrate, whereas the highest amount of monacolin K produced by the mutated strain was 3 times greater than the control culture after the irradiation of UV light in the presence of 1.0 % LiCl in the medium.
author	Sun,Jia-Long Zou,Xiao Liu,Ai-Ying Xiao,Tang-Fu
author_facet	Sun,Jia-Long Zou,Xiao Liu,Ai-Ying Xiao,Tang-Fu
author_sort	Sun,Jia-Long
title	Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
title_short	Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
title_full	Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
title_fullStr	Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
title_full_unstemmed	Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl
title_sort	elevated yield of monacolin k in monascus purpureus by fungal elicitor and mutagenesis of uv and licl
publisher	Sociedad de Biología de Chile
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400010
work_keys_str_mv	AT sunjialong elevatedyieldofmonacolinkinmonascuspurpureusbyfungalelicitorandmutagenesisofuvandlicl AT zouxiao elevatedyieldofmonacolinkinmonascuspurpureusbyfungalelicitorandmutagenesisofuvandlicl AT liuaiying elevatedyieldofmonacolinkinmonascuspurpureusbyfungalelicitorandmutagenesisofuvandlicl AT xiaotangfu elevatedyieldofmonacolinkinmonascuspurpureusbyfungalelicitorandmutagenesisofuvandlicl
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Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl

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