Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers

Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA), 4-nonylphenol (NP) and di(2-ethylhexyl)phthalate (DEHP), and its metabolite mono-2-ethylhexyl phthalate (MEHP) are chemicals found in plastics, which act as endocrine disruptors (EDs) in animals, including human. EDs act like hormones in the endoc...

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Autores principales:	Lagos-Cabré,Raúl, Moreno,Ricardo D
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	Testis spermatogenesis Bisphenol A nonylphenol ADAM17
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100001
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spelling	oai:scielo:S0716-976020120001000012012-05-15Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizersLagos-Cabré,RaúlMoreno,Ricardo D Testis spermatogenesis Bisphenol A nonylphenol ADAM17 Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA), 4-nonylphenol (NP) and di(2-ethylhexyl)phthalate (DEHP), and its metabolite mono-2-ethylhexyl phthalate (MEHP) are chemicals found in plastics, which act as endocrine disruptors (EDs) in animals, including human. EDs act like hormones in the endocrine system, and disrupt the physiologic function of endogenous hormones. Most people are exposed to different endocrine disruptors and concern has been raised about their true effect on reproductive organs. In the testis, they seem to preferentially attack developing testis during puberty rather than adult organs. However, the lack of information about the molecular mechanism, and the apparently controversial effect observed in different models has hampered the understanding of their effects on mammalian spermatogenesis. In this review, we critically discuss the available information regarding the effect of BPA, NP and DEHP/ MEHP upon mammalian spermatogenesis, a major target of EDs. Germ cell sloughing, disruption of the blood-testis-barrier and germ cell apoptosis are the most common effects reported in the available literature. We propose a model at the molecular level to explain the effects at the cellular level, mainly focused on germ cell apoptosis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.1 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100001en10.4067/S0716-97602012000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Testis spermatogenesis Bisphenol A nonylphenol ADAM17
spellingShingle	Testis spermatogenesis Bisphenol A nonylphenol ADAM17 Lagos-Cabré,Raúl Moreno,Ricardo D Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
description	Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA), 4-nonylphenol (NP) and di(2-ethylhexyl)phthalate (DEHP), and its metabolite mono-2-ethylhexyl phthalate (MEHP) are chemicals found in plastics, which act as endocrine disruptors (EDs) in animals, including human. EDs act like hormones in the endocrine system, and disrupt the physiologic function of endogenous hormones. Most people are exposed to different endocrine disruptors and concern has been raised about their true effect on reproductive organs. In the testis, they seem to preferentially attack developing testis during puberty rather than adult organs. However, the lack of information about the molecular mechanism, and the apparently controversial effect observed in different models has hampered the understanding of their effects on mammalian spermatogenesis. In this review, we critically discuss the available information regarding the effect of BPA, NP and DEHP/ MEHP upon mammalian spermatogenesis, a major target of EDs. Germ cell sloughing, disruption of the blood-testis-barrier and germ cell apoptosis are the most common effects reported in the available literature. We propose a model at the molecular level to explain the effects at the cellular level, mainly focused on germ cell apoptosis.
author	Lagos-Cabré,Raúl Moreno,Ricardo D
author_facet	Lagos-Cabré,Raúl Moreno,Ricardo D
author_sort	Lagos-Cabré,Raúl
title	Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
title_short	Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
title_full	Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
title_fullStr	Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
title_full_unstemmed	Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers
title_sort	contribution of environmental pollutants to male infertily: a working model of germ cell apoptosis induced by plasticizers
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100001
work_keys_str_mv	AT lagoscabreraul contributionofenvironmentalpollutantstomaleinfertilyaworkingmodelofgermcellapoptosisinducedbyplasticizers AT morenoricardod contributionofenvironmentalpollutantstomaleinfertilyaworkingmodelofgermcellapoptosisinducedbyplasticizers
_version_	1718441482681057280

Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers

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