IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted...
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| Lenguaje: | English |
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Sociedad de Biología de Chile
2012
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oai:scielo:S0716-976020120002000122012-08-30IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarctionÁvalos,Ana MaríaApablaza,Felipe AQuiroz,MarianaToledo,VivianaPeña,Juan PedroMichea,LuisIrarrazabal,Carlos ECarrión,Flavio AFigueroa,Fernando E Interleukin-17 Th17 myocardial infarction cardiovascular disease Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-β mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinflammatory pathway might play a role in early stages of post MI cardiac remodelling.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012en10.4067/S0716-97602012000200012 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Interleukin-17 Th17 myocardial infarction cardiovascular disease |
| spellingShingle |
Interleukin-17 Th17 myocardial infarction cardiovascular disease Ávalos,Ana María Apablaza,Felipe A Quiroz,Mariana Toledo,Viviana Peña,Juan Pedro Michea,Luis Irarrazabal,Carlos E Carrión,Flavio A Figueroa,Fernando E IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| description |
Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-β mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinflammatory pathway might play a role in early stages of post MI cardiac remodelling. |
| author |
Ávalos,Ana María Apablaza,Felipe A Quiroz,Mariana Toledo,Viviana Peña,Juan Pedro Michea,Luis Irarrazabal,Carlos E Carrión,Flavio A Figueroa,Fernando E |
| author_facet |
Ávalos,Ana María Apablaza,Felipe A Quiroz,Mariana Toledo,Viviana Peña,Juan Pedro Michea,Luis Irarrazabal,Carlos E Carrión,Flavio A Figueroa,Fernando E |
| author_sort |
Ávalos,Ana María |
| title |
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| title_short |
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| title_full |
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| title_fullStr |
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| title_full_unstemmed |
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| title_sort |
il-17a levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2012 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012 |
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