Sonic Hedgehog in cancer stem cells: a novel link with autophagy
The Sonic Hegdehog/GLI (SHH/GLI) pathway has been extensively studied for its role in developmental and cancer biology. During early embryonic development the SHH pathway is involved mainly in pattern formation, while in latter stages its function in stem cell and progenitor proliferation becomes in...
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Sociedad de Biología de Chile
2012
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oai:scielo:S0716-976020120003000042012-12-14Sonic Hedgehog in cancer stem cells: a novel link with autophagyMilla,Luis AGonzález-Ramírez,Claudia NPalma,Verónica Cancer Stem Cells Sonic Hedgehog Cell Survival Autophagy neuroblastoma cancer therapy The Sonic Hegdehog/GLI (SHH/GLI) pathway has been extensively studied for its role in developmental and cancer biology. During early embryonic development the SHH pathway is involved mainly in pattern formation, while in latter stages its function in stem cell and progenitor proliferation becomes increasingly relevant. During postnatal development and in adult tissues, SHH/GLI promotes cell homeostasis by actively regulating gene transcription, recapitulating the function observed during normal tissue growth. In this review, we will briefly discuss the fundamental importance of SHH/GLI in tumor growth and cancer evolution and we will then provide insights into a possible novel mechanism of SHH action in cancer through autophagy modulation in cancer stem cells. Autophagy is a homeostatic mechanism that when disrupted can promote and accelerate tumor progression in both cancer cells and the stroma that harbors tumorigenesis. Understanding possible new targets for SHH signaling and its contribution to cancer through modulation of autophagy might provide better strategies in order to design combined treatments and perform clinical trials.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300004en10.4067/S0716-97602012000300004 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Cancer Stem Cells Sonic Hedgehog Cell Survival Autophagy neuroblastoma cancer therapy |
| spellingShingle |
Cancer Stem Cells Sonic Hedgehog Cell Survival Autophagy neuroblastoma cancer therapy Milla,Luis A González-Ramírez,Claudia N Palma,Verónica Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| description |
The Sonic Hegdehog/GLI (SHH/GLI) pathway has been extensively studied for its role in developmental and cancer biology. During early embryonic development the SHH pathway is involved mainly in pattern formation, while in latter stages its function in stem cell and progenitor proliferation becomes increasingly relevant. During postnatal development and in adult tissues, SHH/GLI promotes cell homeostasis by actively regulating gene transcription, recapitulating the function observed during normal tissue growth. In this review, we will briefly discuss the fundamental importance of SHH/GLI in tumor growth and cancer evolution and we will then provide insights into a possible novel mechanism of SHH action in cancer through autophagy modulation in cancer stem cells. Autophagy is a homeostatic mechanism that when disrupted can promote and accelerate tumor progression in both cancer cells and the stroma that harbors tumorigenesis. Understanding possible new targets for SHH signaling and its contribution to cancer through modulation of autophagy might provide better strategies in order to design combined treatments and perform clinical trials. |
| author |
Milla,Luis A González-Ramírez,Claudia N Palma,Verónica |
| author_facet |
Milla,Luis A González-Ramírez,Claudia N Palma,Verónica |
| author_sort |
Milla,Luis A |
| title |
Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| title_short |
Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| title_full |
Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| title_fullStr |
Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| title_full_unstemmed |
Sonic Hedgehog in cancer stem cells: a novel link with autophagy |
| title_sort |
sonic hedgehog in cancer stem cells: a novel link with autophagy |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2012 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300004 |
| work_keys_str_mv |
AT millaluisa sonichedgehogincancerstemcellsanovellinkwithautophagy AT gonzalezramirezclaudian sonichedgehogincancerstemcellsanovellinkwithautophagy AT palmaveronica sonichedgehogincancerstemcellsanovellinkwithautophagy |
| _version_ |
1718441489271357440 |