Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad de Biología de Chile
2012
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300006 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0716-97602012000300006 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0716-976020120003000062012-12-14Typical and atypical stem cells in the brain, vitamin C effect and neuropathologyNualart,FranciscoSalazar,KatterineOyarce,KarinaCisternas,PedroJara,NerySilva-Álvarez,CarmenPastor,PatriciaMartínez,FernandoGarcía,AndreaGarcía-Robles,María de los ÁngelesTapia,Juan Carlos Stem cells radial glia vitamin C SVCT2 brain development tanycytes Bergmann glia neurogenic niche type B cells neuroblast Parkinson's disease Alzheimer's disease Amyotrophic lateral sclerosis Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the "holy grail" of modern medical neuroscience. Despite their tremendous therapeutic potential, little is known about the mechanisms that regulate their differentiation. In this review, we analyze stem cells in embryonic and adult brains, and illustrate the differentiation pathways that give origin to most brain cells. We also evaluate the emergent role of the well known anti-oxidant, vitamin C, in stem cell differentiation. We believe that a complete understanding of all molecular players, including vitamin C, in stem cell differentiation will positively impact on the use of stem cell transplantation for neurodegenerative diseases.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300006en10.4067/S0716-97602012000300006 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Stem cells radial glia vitamin C SVCT2 brain development tanycytes Bergmann glia neurogenic niche type B cells neuroblast Parkinson's disease Alzheimer's disease Amyotrophic lateral sclerosis |
| spellingShingle |
Stem cells radial glia vitamin C SVCT2 brain development tanycytes Bergmann glia neurogenic niche type B cells neuroblast Parkinson's disease Alzheimer's disease Amyotrophic lateral sclerosis Nualart,Francisco Salazar,Katterine Oyarce,Karina Cisternas,Pedro Jara,Nery Silva-Álvarez,Carmen Pastor,Patricia Martínez,Fernando García,Andrea García-Robles,María de los Ángeles Tapia,Juan Carlos Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| description |
Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and differentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the "holy grail" of modern medical neuroscience. Despite their tremendous therapeutic potential, little is known about the mechanisms that regulate their differentiation. In this review, we analyze stem cells in embryonic and adult brains, and illustrate the differentiation pathways that give origin to most brain cells. We also evaluate the emergent role of the well known anti-oxidant, vitamin C, in stem cell differentiation. We believe that a complete understanding of all molecular players, including vitamin C, in stem cell differentiation will positively impact on the use of stem cell transplantation for neurodegenerative diseases. |
| author |
Nualart,Francisco Salazar,Katterine Oyarce,Karina Cisternas,Pedro Jara,Nery Silva-Álvarez,Carmen Pastor,Patricia Martínez,Fernando García,Andrea García-Robles,María de los Ángeles Tapia,Juan Carlos |
| author_facet |
Nualart,Francisco Salazar,Katterine Oyarce,Karina Cisternas,Pedro Jara,Nery Silva-Álvarez,Carmen Pastor,Patricia Martínez,Fernando García,Andrea García-Robles,María de los Ángeles Tapia,Juan Carlos |
| author_sort |
Nualart,Francisco |
| title |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| title_short |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| title_full |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| title_fullStr |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| title_full_unstemmed |
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology |
| title_sort |
typical and atypical stem cells in the brain, vitamin c effect and neuropathology |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2012 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300006 |
| work_keys_str_mv |
AT nualartfrancisco typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT salazarkatterine typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT oyarcekarina typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT cisternaspedro typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT jaranery typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT silvaalvarezcarmen typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT pastorpatricia typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT martinezfernando typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT garciaandrea typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT garciaroblesmariadelosangeles typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology AT tapiajuancarlos typicalandatypicalstemcellsinthebrainvitaminceffectandneuropathology |
| _version_ |
1718441489686593536 |