Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis

Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Current treatments reduce the relapse rate and the formation of inflammatory lesions in th...

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Autores principales:	Rivera,Francisco J, Aigner,Ludwig
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	multiple sclerosis remyelination oligodendrocyte progenitor cells mesenchymal stem cell therapy and functional recovery
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300007
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spelling	oai:scielo:S0716-976020120003000072012-12-14Adult mesenchymal stem cell therapy for myelin repair in Multiple SclerosisRivera,Francisco JAigner,Ludwig multiple sclerosis remyelination oligodendrocyte progenitor cells mesenchymal stem cell therapy and functional recovery Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Current treatments reduce the relapse rate and the formation of inflammatory lesions in the CNS, but with only temporary and limited success. Despite the presence of endogenous oligodendroglial progenitors (OPCs) and of spontaneous remyelination, at least in early MS its levels and its qualities are apparently insufficient for a sustained endogenous functional repair. Therefore, novel MS therapies should consider not only immunemodulatory but also myelin repair activities. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for MS. MSCs display stromal features and exert bystander immunemodulatory and neuroprotective activities. Importantly, MSCs induce oligodendrocyte fate decision and differentiation/maturation of adult neural progenitors, suggesting the existence of MSC-derived remyelination activity. Moreover, transplanted MSCs promote functional recovery and myelin repair in different MS animal models. Here, we summarize the current knowledge on endogenous mechanisms for remyelination and proposed autologous MSC therapy as a promising strategy for MS treatment.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300007en10.4067/S0716-97602012000300007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	multiple sclerosis remyelination oligodendrocyte progenitor cells mesenchymal stem cell therapy and functional recovery
spellingShingle	multiple sclerosis remyelination oligodendrocyte progenitor cells mesenchymal stem cell therapy and functional recovery Rivera,Francisco J Aigner,Ludwig Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
description	Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Current treatments reduce the relapse rate and the formation of inflammatory lesions in the CNS, but with only temporary and limited success. Despite the presence of endogenous oligodendroglial progenitors (OPCs) and of spontaneous remyelination, at least in early MS its levels and its qualities are apparently insufficient for a sustained endogenous functional repair. Therefore, novel MS therapies should consider not only immunemodulatory but also myelin repair activities. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for MS. MSCs display stromal features and exert bystander immunemodulatory and neuroprotective activities. Importantly, MSCs induce oligodendrocyte fate decision and differentiation/maturation of adult neural progenitors, suggesting the existence of MSC-derived remyelination activity. Moreover, transplanted MSCs promote functional recovery and myelin repair in different MS animal models. Here, we summarize the current knowledge on endogenous mechanisms for remyelination and proposed autologous MSC therapy as a promising strategy for MS treatment.
author	Rivera,Francisco J Aigner,Ludwig
author_facet	Rivera,Francisco J Aigner,Ludwig
author_sort	Rivera,Francisco J
title	Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
title_short	Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
title_full	Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
title_fullStr	Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
title_full_unstemmed	Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis
title_sort	adult mesenchymal stem cell therapy for myelin repair in multiple sclerosis
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300007
work_keys_str_mv	AT riverafranciscoj adultmesenchymalstemcelltherapyformyelinrepairinmultiplesclerosis AT aignerludwig adultmesenchymalstemcelltherapyformyelinrepairinmultiplesclerosis
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Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis

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