Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review

Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions,...

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Autores principales:	Figueroa,Fernando E, Carrión,Flavio, Villanueva,Sandra, Khoury,Maroun
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	Mesenchymal stem cells autoimmune diseases cellular therapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008
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spelling	oai:scielo:S0716-976020120003000082012-12-14Mesenchymal Stem Cell treatment for autoimmune diseases: a critical reviewFigueroa,Fernando ECarrión,FlavioVillanueva,SandraKhoury,Maroun Mesenchymal stem cells autoimmune diseases cellular therapy Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohn's disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future advances from stem cell science can be expected to pinpoint significant MSC subpopulations and/or stem cell markers for improved regenerative or immunoregulatory properties.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008en10.4067/S0716-97602012000300008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mesenchymal stem cells autoimmune diseases cellular therapy
spellingShingle	Mesenchymal stem cells autoimmune diseases cellular therapy Figueroa,Fernando E Carrión,Flavio Villanueva,Sandra Khoury,Maroun Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
description	Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohn's disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future advances from stem cell science can be expected to pinpoint significant MSC subpopulations and/or stem cell markers for improved regenerative or immunoregulatory properties.
author	Figueroa,Fernando E Carrión,Flavio Villanueva,Sandra Khoury,Maroun
author_facet	Figueroa,Fernando E Carrión,Flavio Villanueva,Sandra Khoury,Maroun
author_sort	Figueroa,Fernando E
title	Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
title_short	Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
title_full	Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
title_fullStr	Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
title_full_unstemmed	Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
title_sort	mesenchymal stem cell treatment for autoimmune diseases: a critical review
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008
work_keys_str_mv	AT figueroafernandoe mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT carrionflavio mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT villanuevasandra mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT khourymaroun mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview
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Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review

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