In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis

The formation, maintenance, and repair of bone tissue involve close interlinks between two stem cell types housed in the bone marrow: the hematologic stem cell originating osteoclasts and mesenchymal stromal cells (MSCs) generating osteoblasts. In this review, we consider malfunctioning of MSCs as e...

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Autores principales:	Pino,Ana María, Rosen,Clifford J, Rodríguez,J. Pablo
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	MSCs osteoporosis adipogenesis bone marrow microenvironment
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300009
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spelling	oai:scielo:S0716-976020120003000092012-12-14In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesisPino,Ana MaríaRosen,Clifford JRodríguez,J. Pablo MSCs osteoporosis adipogenesis bone marrow microenvironment The formation, maintenance, and repair of bone tissue involve close interlinks between two stem cell types housed in the bone marrow: the hematologic stem cell originating osteoclasts and mesenchymal stromal cells (MSCs) generating osteoblasts. In this review, we consider malfunctioning of MSCs as essential for osteoporosis. In osteoporosis, increased bone fragility and susceptibility to fractures result from increased osteoclastogenesis and insufficient osteoblastogenesis. MSCs are the common precursors for both osteoblasts and adipocytes, among other cell types. MSCs' commitment towards either the osteoblast or adipocyte lineages depends on suitable regulatory factors activating lineage-specific transcriptional regulators. In osteoporosis, the reciprocal balance between the two differentiation pathways is altered, facilitating adipose accretion in bone marrow at the expense of osteoblast formation; suggesting that under this condition MSCs activity and their microenvironment may be disturbed. We summarize research on the properties of MSCs isolated from the bone marrow of control and osteoporotic post-menopausal women. Our observations indicate that intrinsic properties of MSCs are disturbed in osteoporosis. Moreover, we found that the regulatory conditions in the bone marrow fluid of control and osteoporotic patients are significantly different. These conclusions should be relevant for the use of MSCs in therapeutic applications.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300009en10.4067/S0716-97602012000300009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	MSCs osteoporosis adipogenesis bone marrow microenvironment
spellingShingle	MSCs osteoporosis adipogenesis bone marrow microenvironment Pino,Ana María Rosen,Clifford J Rodríguez,J. Pablo In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
description	The formation, maintenance, and repair of bone tissue involve close interlinks between two stem cell types housed in the bone marrow: the hematologic stem cell originating osteoclasts and mesenchymal stromal cells (MSCs) generating osteoblasts. In this review, we consider malfunctioning of MSCs as essential for osteoporosis. In osteoporosis, increased bone fragility and susceptibility to fractures result from increased osteoclastogenesis and insufficient osteoblastogenesis. MSCs are the common precursors for both osteoblasts and adipocytes, among other cell types. MSCs' commitment towards either the osteoblast or adipocyte lineages depends on suitable regulatory factors activating lineage-specific transcriptional regulators. In osteoporosis, the reciprocal balance between the two differentiation pathways is altered, facilitating adipose accretion in bone marrow at the expense of osteoblast formation; suggesting that under this condition MSCs activity and their microenvironment may be disturbed. We summarize research on the properties of MSCs isolated from the bone marrow of control and osteoporotic post-menopausal women. Our observations indicate that intrinsic properties of MSCs are disturbed in osteoporosis. Moreover, we found that the regulatory conditions in the bone marrow fluid of control and osteoporotic patients are significantly different. These conclusions should be relevant for the use of MSCs in therapeutic applications.
author	Pino,Ana María Rosen,Clifford J Rodríguez,J. Pablo
author_facet	Pino,Ana María Rosen,Clifford J Rodríguez,J. Pablo
author_sort	Pino,Ana María
title	In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
title_short	In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
title_full	In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
title_fullStr	In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
title_full_unstemmed	In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis
title_sort	in osteoporosis, differentiation of mesenchymal stem cells (mscs) improves bone marrow adipogenesis
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300009
work_keys_str_mv	AT pinoanamaria inosteoporosisdifferentiationofmesenchymalstemcellsmscsimprovesbonemarrowadipogenesis AT rosencliffordj inosteoporosisdifferentiationofmesenchymalstemcellsmscsimprovesbonemarrowadipogenesis AT rodriguezjpablo inosteoporosisdifferentiationofmesenchymalstemcellsmscsimprovesbonemarrowadipogenesis
_version_	1718441490465685504

In Osteoporosis, differentiation of mesenchymal stem cells (MSCs) improves bone marrow adipogenesis

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