MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy

Currently, one of the main threats to public health is diabetes mellitus. Its most detrimental complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known t...

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Autores principales:	Ezquer,Marcelo E, Ezquer,Fernando E, Arango-Rodríguez,Martha L, Conget,Paulette A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	Regenerative medicine Diabetes mellitus Diabetic nephropathy Multipotent mesenchymal stromal cells Mesenchymal stem cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300010
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spelling	oai:scielo:S0716-976020120003000102012-12-14MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathyEzquer,Marcelo EEzquer,Fernando EArango-Rodríguez,Martha LConget,Paulette A Regenerative medicine Diabetes mellitus Diabetic nephropathy Multipotent mesenchymal stromal cells Mesenchymal stem cells Currently, one of the main threats to public health is diabetes mellitus. Its most detrimental complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. The earliest detectable signs are microalbuminuria and histopathological changes including extracellular matrix deposition, glomerular basement membrane thickening, glomerular and mesangial expansion. Later on macroalbuminuria appears, followed by a progressive decline in glomerular filtration rate and the loss of glomerular podocytes, tubulointerstitial fibrosis, glomerulosclerosis and arteriolar hyalinosis. Tight glycemic and hypertension controls remain the key factors for preventing or arresting the progression of DN. Nevertheless, despite considerable educational effort to control the disease, a significant number of patients not only develop DN, but also progress to chronic kidney disease. Therefore, the availability of a strategy aimed to prevent, delay or revert DN would be highly desirable. In this article, we review the pathophysiological features of DN and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs). The perfect match between them, together with encouraging pre-clinical data available, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage DN onset and progression, not only because of the safety of this procedure, but mainly because of the renoprotective potential of MSCs.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300010en10.4067/S0716-97602012000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Regenerative medicine Diabetes mellitus Diabetic nephropathy Multipotent mesenchymal stromal cells Mesenchymal stem cells
spellingShingle	Regenerative medicine Diabetes mellitus Diabetic nephropathy Multipotent mesenchymal stromal cells Mesenchymal stem cells Ezquer,Marcelo E Ezquer,Fernando E Arango-Rodríguez,Martha L Conget,Paulette A MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
description	Currently, one of the main threats to public health is diabetes mellitus. Its most detrimental complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. The earliest detectable signs are microalbuminuria and histopathological changes including extracellular matrix deposition, glomerular basement membrane thickening, glomerular and mesangial expansion. Later on macroalbuminuria appears, followed by a progressive decline in glomerular filtration rate and the loss of glomerular podocytes, tubulointerstitial fibrosis, glomerulosclerosis and arteriolar hyalinosis. Tight glycemic and hypertension controls remain the key factors for preventing or arresting the progression of DN. Nevertheless, despite considerable educational effort to control the disease, a significant number of patients not only develop DN, but also progress to chronic kidney disease. Therefore, the availability of a strategy aimed to prevent, delay or revert DN would be highly desirable. In this article, we review the pathophysiological features of DN and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs). The perfect match between them, together with encouraging pre-clinical data available, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage DN onset and progression, not only because of the safety of this procedure, but mainly because of the renoprotective potential of MSCs.
author	Ezquer,Marcelo E Ezquer,Fernando E Arango-Rodríguez,Martha L Conget,Paulette A
author_facet	Ezquer,Marcelo E Ezquer,Fernando E Arango-Rodríguez,Martha L Conget,Paulette A
author_sort	Ezquer,Marcelo E
title	MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
title_short	MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
title_full	MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
title_fullStr	MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
title_full_unstemmed	MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
title_sort	msc transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300010
work_keys_str_mv	AT ezquermarceloe msctransplantationapromisingtherapeuticstrategytomanagetheonsetandprogressionofdiabeticnephropathy AT ezquerfernandoe msctransplantationapromisingtherapeuticstrategytomanagetheonsetandprogressionofdiabeticnephropathy AT arangorodriguezmarthal msctransplantationapromisingtherapeuticstrategytomanagetheonsetandprogressionofdiabeticnephropathy AT congetpaulettea msctransplantationapromisingtherapeuticstrategytomanagetheonsetandprogressionofdiabeticnephropathy
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MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy

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