Hematopoietic stem cell transplantation: clinical use and perspectives

Hematopoietic stem cell transplantation is the accepted therapy of choice for a variety of malignant and non-malignant diseases in children and adults. Initially developed as rescue therapy for a patient with cancer after high doses of chemotherapy and radiation as well as the correction of severe d...

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Autores principales:	Barriga,Francisco, Ramírez,Pablo, Wietstruck,Angélica, Rojas,Nicolás
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2012
Materias:	hematopoietic stem cells transplantation allogeneic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300012
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spelling	oai:scielo:S0716-976020120003000122012-12-14Hematopoietic stem cell transplantation: clinical use and perspectivesBarriga,FranciscoRamírez,PabloWietstruck,AngélicaRojas,Nicolás hematopoietic stem cells transplantation allogeneic Hematopoietic stem cell transplantation is the accepted therapy of choice for a variety of malignant and non-malignant diseases in children and adults. Initially developed as rescue therapy for a patient with cancer after high doses of chemotherapy and radiation as well as the correction of severe deficiencies in the hematopoietic system, it has evolved into an adoptive immune therapy for malignancies and autoimmune disorders. The procedure has helped to obtain key information about the bone marrow environment, the biology of hematopoietic stem cells and histocompatibility. The development of this new discipline has allowed numerous groups working around the world to cure patients of diseases previously considered lethal. Together with the ever growing list of volunteer donors and umbilical cord blood banks, this has resulted in life saving therapy for thousands of patients yearly. We present an overview of the procedure from its cradle to the most novel applications, as well as the results of the HSC transplant program developed at our institution since 1989.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.45 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300012en10.4067/S0716-97602012000300012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	hematopoietic stem cells transplantation allogeneic
spellingShingle	hematopoietic stem cells transplantation allogeneic Barriga,Francisco Ramírez,Pablo Wietstruck,Angélica Rojas,Nicolás Hematopoietic stem cell transplantation: clinical use and perspectives
description	Hematopoietic stem cell transplantation is the accepted therapy of choice for a variety of malignant and non-malignant diseases in children and adults. Initially developed as rescue therapy for a patient with cancer after high doses of chemotherapy and radiation as well as the correction of severe deficiencies in the hematopoietic system, it has evolved into an adoptive immune therapy for malignancies and autoimmune disorders. The procedure has helped to obtain key information about the bone marrow environment, the biology of hematopoietic stem cells and histocompatibility. The development of this new discipline has allowed numerous groups working around the world to cure patients of diseases previously considered lethal. Together with the ever growing list of volunteer donors and umbilical cord blood banks, this has resulted in life saving therapy for thousands of patients yearly. We present an overview of the procedure from its cradle to the most novel applications, as well as the results of the HSC transplant program developed at our institution since 1989.
author	Barriga,Francisco Ramírez,Pablo Wietstruck,Angélica Rojas,Nicolás
author_facet	Barriga,Francisco Ramírez,Pablo Wietstruck,Angélica Rojas,Nicolás
author_sort	Barriga,Francisco
title	Hematopoietic stem cell transplantation: clinical use and perspectives
title_short	Hematopoietic stem cell transplantation: clinical use and perspectives
title_full	Hematopoietic stem cell transplantation: clinical use and perspectives
title_fullStr	Hematopoietic stem cell transplantation: clinical use and perspectives
title_full_unstemmed	Hematopoietic stem cell transplantation: clinical use and perspectives
title_sort	hematopoietic stem cell transplantation: clinical use and perspectives
publisher	Sociedad de Biología de Chile
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300012
work_keys_str_mv	AT barrigafrancisco hematopoieticstemcelltransplantationclinicaluseandperspectives AT ramirezpablo hematopoieticstemcelltransplantationclinicaluseandperspectives AT wietstruckangelica hematopoieticstemcelltransplantationclinicaluseandperspectives AT rojasnicolas hematopoieticstemcelltransplantationclinicaluseandperspectives
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Hematopoietic stem cell transplantation: clinical use and perspectives

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